Regulation of CRISPR-Cas12a system by methylation and demethylation of Guide RNA
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DOI: 10.1039/d3sc00629h
Abstract: Chemical modifications of CRISPR-Cas nucleases help decrease off-target editing and expand the biomedical applications of CRISPR-based gene manipulation tools. Here, we found that epigenetic modifications of guide RNA, such as m6A and m1A methylation, can… read more here.
Keywords: crispr cas12a; regulation crispr; methylation; guide rna ... See more keywords