Regulation and function of p53: A perspective from Drosophila studies
Sign Up to like & getrecommendations! Published in 2018 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2018.05.007
Abstract: Tp53 is a central regulator of cellular responses to stress and one of the most frequently mutated genes in human cancers. P53 is activated by a myriad of stress signals and drives specific cellular responses… read more here.
Keywords: function p53; drosophila studies; p53 perspective; regulation function ... See more keywords
Fungal secondary metabolism: regulation, function and drug discovery
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Microbiology"
DOI: 10.1038/s41579-018-0121-1
Abstract: One of the exciting movements in microbial sciences has been a refocusing and revitalization of efforts to mine the fungal secondary metabolome. The magnitude of biosynthetic gene clusters (BGCs) in a single filamentous fungal genome… read more here.
Keywords: metabolism regulation; secondary metabolism; regulation function; fungal secondary ... See more keywords
Regulation and function of elF2B in neurological and metabolic disorders
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20211699
Abstract: Abstract Eukaryotic initiation factor 2B, eIF2B is a guanine nucleotide exchange, factor with a central role in coordinating the initiation of translation. During stress and disease, the activity of eIF2B is inhibited via the phosphorylation… read more here.
Keywords: role; disease; regulation function; neurological metabolic ... See more keywords
Regulation and function of interleukin‐36 cytokines
Sign Up to like & getrecommendations! Published in 2018 at "Immunological Reviews"
DOI: 10.1111/imr.12610
Abstract: The interleukin (IL)‐36 cytokines include 3 agonists, IL‐36α, IL‐36β, and IL‐36γ that bind to a common receptor composed of IL‐36R and IL‐1RAcP to stimulate inflammatory responses. IL‐36Ra is a natural antagonist that binds to IL‐36R,… read more here.
Keywords: function interleukin; interleukin cytokines; pathology; physiology ... See more keywords
Regulation and Function of RNA Pseudouridylation in Human Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Annual review of genetics"
DOI: 10.1146/annurev-genet-112618-043830
Abstract: Recent advances in pseudouridine detection reveal a complex pseudouridine landscape that includes messenger RNA and diverse classes of noncoding RNA in human cells. The known molecular functions of pseudouridine, which include stabilizing RNA conformations and… read more here.
Keywords: pseudouridylation; genetics; rna pseudouridylation; function rna ... See more keywords
mTORC1 and 2 adrenergic regulation and function in brown adipose tissue.
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.00023.2024
Abstract: Brown adipose tissue (BAT) thermogenesis results from the uncoupling of mitochondrial inner membrane proton gradient mediated by the uncoupling protein 1 (UCP-1), which is activated by lipolysis-derived fatty acids. Norepinephrine (NE) secreted by sympathetic innervation… read more here.
Keywords: regulation function; adrenergic regulation; mtorc1 adrenergic; adipose tissue ... See more keywords
The Exosome Journey: From Biogenesis to Regulation and Function in Cancers
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/9356807
Abstract: Exosomes are a type of small endosomal-derived vesicles ranging from 30 to 150 nm, which can serve as functional mediators in cell-to-cell communication and various physiological and pathological processes. In recent years, exosomes have emerged as… read more here.
Keywords: biogenesis regulation; regulation function; regulation; function cancers ... See more keywords
Regulation to function: A computational approach to specialized metabolism
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3003205
Abstract: Despite a century of use in drug discovery, specialized metabolism continues to churn out astonishing discoveries. A new study in PLOS Biology uses a novel computational approach to uncover previously unknown functions of a compound… read more here.
Keywords: specialized metabolism; regulation function; biology; computational approach ... See more keywords
Regulation and Function of Chemokines at the Maternal–Fetal Interface
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.826053
Abstract: Successful pregnancy requires the maternal immune system to tolerate the semi-allogeneic embryo. A good trophoblast function is also essential for successful embryo implantation and subsequent placental development. Chemokines are initially described in recruiting leukocytes. There… read more here.
Keywords: fetal interface; pregnancy; regulation function; maternal fetal ... See more keywords
Structure, Regulation, and Function of Linear and Circular Long Non-Coding RNAs
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.00150
Abstract: Long non-coding RNAs (lncRNAs), including linear lncRNAs and circular RNAs (circRNAs), exhibit a surprising range of structures. Linear lncRNAs and circRNAs are generated by different pathways. Linear lncRNAs perform functions that depend on their specific… read more here.
Keywords: coding rnas; linear lncrnas; long non; non coding ... See more keywords
Regulation and Function of Metal Uptake Transporter NtNRAMP3 in Tobacco
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.867967
Abstract: Natural resistance-associated macrophage protein (NRAMP) genes encode proteins with low substrate specificity, important for maintaining metal cross homeostasis in the cell. The role of these proteins in tobacco, an important crop plant with wide application… read more here.
Keywords: regulation function; ntnramp3; function metal; tobacco ... See more keywords