Constitutive downregulation protein kinase C epsilon in hSOD1G93A astrocytes influences mGluR5 signaling and the regulation of glutamate uptake
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DOI: 10.1002/glia.23279
Abstract: Accumulating evidence indicates that motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is a non‐cell‐autonomous process and that impaired glutamate clearance by astrocytes, leading to excitotoxicity, could participate in progression of the disease. In astrocytes… read more here.
Keywords: glutamate uptake; glutamate; mglur5 activation; regulation glutamate ... See more keywords
Rapid Regulation of Glutamate Transport: Where Do We Go from Here?
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DOI: 10.1007/s11064-021-03329-7
Abstract: Glutamate is the predominant excitatory neurotransmitter in the mammalian central nervous system (CNS). A family of five Na+-dependent transporters maintain low levels of extracellular glutamate and shape excitatory signaling. Shortly after the research group of… read more here.
Keywords: group; glutamate transport; rapid regulation; regulation glutamate ... See more keywords