Brown adipose tissue and regulation of human body weight
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3594
Abstract: Approximately 30% of the global population is affected by obesity. Traditional non‐surgical measures for weight loss have limited efficacy and tolerability. Therefore, there is a need for novel, effective therapies. Brown adipose tissue (BAT) has… read more here.
Keywords: regulation human; brown adipose; adipose tissue; human body ... See more keywords
Polycomb‐mediated gene regulation in human brain development and neurodevelopmental disorders
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22876
Abstract: The neocortex is considered the seat of higher cognitive function in humans. It develops from a sheet of neural progenitor cells, most of which eventually give rise to neurons. This process of cell fate determination… read more here.
Keywords: neurodevelopmental disorders; pcg; development; regulation human ... See more keywords
Human Peroxisomal 3-Ketoacyl-CoA Thiolase: Tissue Expression and Metabolic Regulation : Human Peroxisomal Thiolase.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-60204-8_12
Abstract: This paper reports that the human peroxisomal 3-ketoacyl-CoA thiolase expression shows three transcripts: Tr1 (1705 bp), Tr2 (1375 bp) and Tr3 (1782 bp). Their highest expression is observed in the human liver and at a lesser extent in… read more here.
Keywords: human peroxisomal; regulation human; peroxisomal ketoacyl; expression ... See more keywords
Epigenetic Regulation of Human Neural Stem Cell Differentiation.
Sign Up to like & getrecommendations! Published in 2018 at "Results and problems in cell differentiation"
DOI: 10.1007/978-3-319-93485-3_5
Abstract: Emerging evidence has demonstrated that epigenetic programs influence many aspects of neural stem cell (NSC) behavior, including proliferation and differentiation. It is becoming apparent that epigenetic mechanisms, such as DNA methylation, histone modifications, and noncoding… read more here.
Keywords: regulation human; stem cell; differentiation; stem ... See more keywords
Structural basis for the activity and regulation of human α-ketoglutarate dehydrogenase revealed by Cryo-EM.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.02.093
Abstract: The human mitochondrial alpha-ketoglutarate (α-KG) dehydrogenase complex (hKGDHc) is a well-studied macromolecular enzyme that converts α-KG to succinyl-CoA and NADH. Abnormalities of the complex lead to several diseases, including neurodegenerative disorders. Despite its importance in… read more here.
Keywords: regulation human; activity regulation; structural basis; dehydrogenase ... See more keywords
Regulation of Human Mcl-1 by a Divergently-Expressed Antisense Transcript.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.145016
Abstract: Mcl-1 is a member of the Bcl-2 anti-apoptotic protein family with important roles in the development, lifespan and metabolism of lymphocytes, as well as oncogenesis. Mcl-1 displays the shortest half-life of all Bcl-2 family members,… read more here.
Keywords: mcl; mcl expression; regulation human; mcl1 as1 ... See more keywords
Regulation of Human Osteoblast-to-Osteocyte Differentiation by Direct-Write 3D Microperiodic Hydroxyapatite Scaffolds
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.8b03272
Abstract: Culturing osteocytes on planer surfaces on Petri dish in vitro fails to recapitulate their natural orientation as well as biological functionality in human bone. Ability to recapitulate spatial arr... read more here.
Keywords: direct write; human osteoblast; regulation human; osteocyte differentiation ... See more keywords
Structural basis for allosteric regulation of Human Topoisomerase IIα
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23136-6
Abstract: The human type IIA topoisomerases (Top2) are essential enzymes that regulate DNA topology and chromosome organization. The Topo IIα isoform is a prime target for antineoplastic compounds used in cancer therapy that form ternary cleavage… read more here.
Keywords: human topoisomerase; structural basis; allosteric regulation; basis allosteric ... See more keywords
Epigenetic regulation of human non-coding RNA gene transcription.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society transactions"
DOI: 10.1042/bst20210860
Abstract: Recent investigations on the non-protein-coding transcriptome of human cells have revealed previously hidden layers of gene regulation relying on regulatory non-protein-coding (nc) RNAs, including the widespread ncRNA-dependent regulation of epigenetic chromatin states and of mRNA… read more here.
Keywords: regulation human; epigenetic regulation; regulation; gene transcription ... See more keywords
Framing and legitimating EU legal regulation of human gene-editing technologies: key facets and functions of an imaginary
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Law and the Biosciences"
DOI: 10.1093/jlb/lsaa080
Abstract: ABSTRACT Gene-editing technologies, ie those able to make changes in the DNA of an organism, are the object of global competition and a regulatory race between countries and regions. There is an attempt to craft… read more here.
Keywords: gene editing; editing technologies; legal regulation; regulation human ... See more keywords
Trust, regulation, and human-in-the-loop AI
Sign Up to like & getrecommendations! Published in 2022 at "Communications of the ACM"
DOI: 10.1145/3511597
Abstract: intention to accept vulnerability based upon positive expectations of the intentions or behavior of another.” Trust is an attitude that an agent will behave as expected and can be relied upon to reach its goal.… read more here.
Keywords: trust regulation; human loop; regulation human; trust ... See more keywords