GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.03.006
Abstract: Inflammatory signaling is restricted through degradation and the translational repression of cytokine mRNAs. A key factor in this regulation is tristetraprolin (TTP), an RNA-binding protein (RBP) that recruits RNA-destabilizing factors and the translation inhibitory complex… read more here.
Keywords: regulation inflammatory; znf598; inflammatory signaling; regulation ... See more keywords
Down regulation of inflammatory cytokines by the bioactive resveratrol-loaded chitoniosomes in induced ocular inflammation model
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2021.102787
Abstract: Abstract Resveratrol (RSV); a natural polyphenol possess anti-inflammatory property through reduction of proinflammatory cytokines tumor-necrosis factor-alpha (TNFα) and interleukin (IL)-6 which play a key role in eye inflammation. Ocular inflammation results in irreversible tissues damage… read more here.
Keywords: ocular inflammation; inflammatory cytokines; bioactive resveratrol; regulation inflammatory ... See more keywords
Peroxiredoxin‐2 up‐regulation in inflammatory bowel disease: Friend or foe?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.13664
Abstract: Inflammatory bowel diseases (IBD) are chronic multi‐factorial inflammatory disorders. Accumulating investigations have provided compelling evidence that describe the interplay of a complex genetic landscape and inappropriate inflammatory response to intestinal microbes in disease etiopathogenesis but… read more here.
Keywords: bowel; regulation inflammatory; inflammatory bowel; disease ... See more keywords
Abstract 5028: The regulation of inflammatory signaling in cancer via A20 phosphorylation
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5028
Abstract: A20 is an anti-inflammatory protein with a dual ubiquitin-editing activity. Through its N-terminal ovarian tumor (OTU) domain, A20 negatively regulates NF-ĸB by removing the K63-linked ubiquitin chains on RIP1 that act as platforms for NF-ĸB… read more here.
Keywords: a20; a20 phosphorylation; activity; regulation inflammatory ... See more keywords
Maternal regulation of inflammatory cues is required for induction of preterm birth
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.138812
Abstract: Infection-driven inflammation in pregnancy is a major cause of spontaneous preterm birth (PTB). Both systemic infection and bacterial ascension through the vagina/cervix to the amniotic cavity are strongly associated with PTB. However, the contribution of… read more here.
Keywords: driven ptb; regulation inflammatory; maternal regulation; preterm birth ... See more keywords
Withaferin A Associated Differential Regulation of Inflammatory Cytokines
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00195
Abstract: A role of inflammation-associated cytokines/chemokines has been implicated in a wide variety of human diseases. Here, we investigated the regulation of inflammatory cytokines released by monocyte-derived THP-1 cells following treatment with the dietary agent withaferin… read more here.
Keywords: cytokines chemokines; differential regulation; inflammatory cytokines; regulation inflammatory ... See more keywords
Density dependent regulation of inflammatory responses in macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.895488
Abstract: Macrophage distribution density is tightly regulated within the body, yet the importance of macrophage crowding during in vitro culture is largely unstudied. Using a human induced pluripotent stem cell (iPSC)-derived macrophage model of tissue resident… read more here.
Keywords: cell; density; dependent regulation; density dependent ... See more keywords