Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109541
Abstract: The regulation of lipid homeostasis is not well understood. Using forward genetic screening, we demonstrate that the loss of dTBC1D22, an essential gene that encodes a Tre2-Bub2-Cdc16 (TBC) domain-containing protein, results in lipid droplet accumulation… read more here.
Keywords: lipophagy; regulation lipid; rab40; lipid homeostasis ... See more keywords
OSBPL2 Is Required for the Binding of COPB1 to ATGL and the Regulation of Lipid Droplet Lipolysis
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101252
Abstract: Summary The accumulation of giant lipid droplets (LDs) increases the risk of metabolic disorders including obesity and insulin resistance. The lipolysis process involves the activation and transfer of lipase, but the molecular mechanism is not… read more here.
Keywords: lipolysis; regulation lipid; lipid droplet; droplet lipolysis ... See more keywords
CREBH regulation of lipid metabolism through multifaceted functions that improve arteriosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13766
Abstract: Cyclic adenosine monophosphate‐responsive element‐binding protein H (CREBH) activates lipoprotein lipase (LPL) activity by modulating apolipoproteins. Activated LPL hydrolyzes triglyceride‐rich lipoproteins, such as very low‐density lipoprotein (VLDL) and chylomicrons, resulting in remnant lipoproteins. CREBH increases apolipoprotein… read more here.
Keywords: clearance; regulation lipid; lipid metabolism; crebh regulation ... See more keywords
Regulation of lipid droplets in live preadipocytes using optical diffraction tomography and Raman spectroscopy.
Sign Up to like & getrecommendations! Published in 2019 at "Optics express"
DOI: 10.1364/oe.27.022994
Abstract: Lipid droplets have gained strong interest in recent years to comprehend how they function and coordinate with other parts of the cell. However, it remains challenging to study the regulation of lipid droplets in live… read more here.
Keywords: regulation lipid; live preadipocytes; spectroscopy; droplets live ... See more keywords
Homeostatic regulation of lipid droplet content in mammalian oocytes and embryos.
Sign Up to like & getrecommendations! Published in 2021 at "Reproduction"
DOI: 10.1530/rep-21-0238
Abstract: Lipid droplets (LDs) consist of a core of neutral lipids such as triacylglycerols and cholesteryl esters covered by a phospholipid monolayer. Recent studies have shown that LDs not only store neutral lipids but are also… read more here.
Keywords: regulation lipid; content; embryonic development; mammalian oocytes ... See more keywords