Quantifying Dynamic Regulation in Metabolic Pathways with Nonparametric Flux Inference.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.04.009
Abstract: One of the central tasks in systems biology is to understand how cells regulate their metabolism. Hierarchical regulation analysis is a powerful tool to study this regulation at the metabolic, gene-expression, and signaling levels. It… read more here.
Keywords: regulation analysis; quantifying dynamic; hierarchical regulation; regulation ... See more keywords
Regulation of metabolic health and aging by nutrient-sensitive signaling pathways
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2016.11.014
Abstract: All organisms need to be capable of adapting to changes in the availability and composition of nutrients. Over 75 years ago, researchers discovered that a calorie restricted (CR) diet could significantly extend the lifespan of… read more here.
Keywords: metabolic health; health aging; aging nutrient; composition ... See more keywords
Centennial Review: Metabolic microRNA - shifting gears in the regulation of metabolic pathways in poultry
Sign Up to like & getrecommendations! Published in 2021 at "Poultry Science"
DOI: 10.1016/j.psj.2020.11.033
Abstract: Over 20 yr ago, a small noncoding class of RNA termed microRNA (miRNA) that was able to recognize sequences in mRNAs and inhibit their translation was discovered in Caenorhabditis elegans. In the intervening years, miRNA… read more here.
Keywords: mirna; metabolism; review metabolic; regulation metabolic ... See more keywords
Regulation and metabolic functions of mTORC1 and mTORC2.
Sign Up to like & getrecommendations! Published in 2021 at "Physiological reviews"
DOI: 10.1152/physrev.00026.2020
Abstract: Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and proliferation. The uptake of nutrients from the environment and their intracellular metabolism is a highly controlled process that involves crosstalk between growth signaling… read more here.
Keywords: metabolism; functions mtorc1; mtor; regulation metabolic ... See more keywords
Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors
Sign Up to like & getrecommendations! Published in 2018 at "Mediators of Inflammation"
DOI: 10.1155/2018/8261432
Abstract: Visceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic β-cell dysfunction as important hallmarks. Recent evidence indicates that the chronic,… read more here.
Keywords: metabolic disease; inflammation; regulation metabolic; associated inflammation ... See more keywords