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Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149691
Abstract: The CD11c+ MHCII+ compartment within GM-CSF cultures consists of a MHCIIlow CD11bhigh population (GM-Macs) and a MHCIIhigh CD11bint population (GM-DCs), with different metabolic profiles. GM-Macs upregulate iNOS and produce nitric oxide (NO) upon TLR activation…
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Keywords:
metabolism nitric;
nitric oxide;
regulation metabolism;
csf cultures ... See more keywords
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Published in 2019 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2018.09.017
Abstract: A broad range of biochemicals, from proteins to nucleic acids, function properly only when associated with a metal, usually a divalent cation. Not any divalent metal will do: these metals differ in their ionic radius,…
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Keywords:
regulation metabolism;
metabolism;
metal;
biology ... See more keywords
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Published in 2021 at "Cell stem cell"
DOI: 10.1016/j.stem.2021.02.017
Abstract: The depth of quiescence in hematopoietic stem cells (HSCs) dictates their potency and is sensitive to metabolic perturbations. Recent evidence suggests that lysosomal functions distinct from autophagic processes are pivotal in regulating quiescence versus activation…
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Keywords:
regulation metabolism;
hematopoietic stem;
lysosomal regulation;
stem cells ... See more keywords
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Published in 2017 at "Aging Cell"
DOI: 10.1111/acel.12689
Abstract: Cellular metabolism is regulated by the mTOR kinase, a key component of the molecular nutrient sensor pathway that plays a central role in cellular survival and aging. The mTOR pathway promotes protein and lipid synthesis…
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Keywords:
regulation metabolism;
mediated regulation;
tor mediated;
metabolism ... See more keywords