Pathogenic mutations perturb calmodulin regulation of Nav1.8 channel.
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DOI: 10.1016/j.bbrc.2020.08.010
Abstract: The voltage-gated sodium channels play a key role in the generation and propagation of the cardiac action potential. Emerging data indicate that the Nav1.8 channel, encoded by the SCN10A gene, is a modulator of cardiac… read more here.
Keywords: cam; regulation nav1; channel; inactivation ... See more keywords