The regulation of NLRP3 inflammasome activation by CCDC50-mediated autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2080957
Abstract: ABSTRACT The assembly of the NLRP3 inflammasome can be initiated by a wide range of stimuli including exogenous infection as well as endogenous damage. Therefore, the tight regulation of the NLRP3 inflammasome is crucial for… read more here.
Keywords: inflammation; ccdc50; autophagy regulation; regulation nlrp3 ... See more keywords
Effect and Regulation of the NLRP3 Inflammasome During Renal Fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2019.00379
Abstract: Renal fibrosis is a common pathological process where certain primary or secondary kidney diseases can continue to progress to the end-stage of the kidney disease; however, the molecular mechanisms underlying renal fibrosis remain unclear. Recently,… read more here.
Keywords: fibrosis; renal fibrosis; nlrp3 inflammasome; regulation nlrp3 ... See more keywords
Regulation of the NLRP3 Inflammasome by Post-Translational Modifications and Small Molecules
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.618231
Abstract: Inflammation is a host protection mechanism that eliminates invasive pathogens from the body. However, chronic inflammation, which occurs repeatedly and continuously over a long period, can directly damage tissues and cause various inflammatory and autoimmune… read more here.
Keywords: modifications small; post translational; nlrp3 inflammasome; translational modifications ... See more keywords
N-Lobe of TXNIP Is Critical in the Allosteric Regulation of NLRP3 via TXNIP Binding
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.893919
Abstract: Inflammasomes are cytoplasmic complexes that form in response to exogenous microbial invasions and endogenous damage signals. Among the known inflammasomes, the activation of the NACHT (NAIP, CIITA, HET-E, and TP1 domain), leucine-rich repeat, and pyrin… read more here.
Keywords: allosteric regulation; txnip; nlrp3 interaction; regulation nlrp3 ... See more keywords
The Mechanism and Regulation of the NLRP3 Inflammasome during Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12050634
Abstract: Fibrosis is often the end result of chronic inflammation. It is characterized by the excessive deposition of extracellular matrix. This leads to structural alterations in the tissue, causing permanent damage and organ dysfunction. Depending on… read more here.
Keywords: regulation nlrp3; fibrosis; mechanism regulation; nlrp3 inflammasome ... See more keywords