Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.09.006
Abstract: Autoimmunity is prevented by the function of the autoimmune regulator [AIRE (Aire in mice)], which promotes the expression of a wide variety of tissue-restricted antigens (TRAs) from medullary thymic epithelial cells (mTECs) and from a… read more here.
Keywords: aire; autoimmune regulator; expression; autoimmunity ... See more keywords
Autoimmune regulator (AIRE): Takes a hypoxia‐inducing factor 1A (HIF1A) route to regulate FOXP3 expression in PCOS
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13637
Abstract: Autoimmune polyendocrinopathy‐candidiasis‐ ectodermal dystrophy (APECED) pathology due to autoimmune regulator (AIRE) gene mutations leads to loss of central tolerance triggering immune attack, a factor causing infertility. One of the targets of autoimmune attack is ovary… read more here.
Keywords: factor; aire; regulator aire; autoimmune regulator ... See more keywords
The Autoimmune Regulator (Aire) transactivates HLA‐G gene expression in thymic epithelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1111/imm.13099
Abstract: The Autoimmune Regulator (Aire) protein coordinates the negative selection of developing thymocytes by inducing the expression of hundreds of tissue‐specific antigens within the thymic medulla, which is also a primary site of the expression of… read more here.
Keywords: aire; regulator aire; autoimmune regulator; hla ... See more keywords