A pan-cancer assessment of alterations of the kinase domain of ULK1, an upstream regulator of autophagy
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DOI: 10.1038/s41598-020-71527-4
Abstract: Autophagy is a key clearance process to recycle damaged cellular components. One important upstream regulator of autophagy is ULK1 kinase. Several three-dimensional structures of the ULK1 catalytic domain are available, but a comprehensive study, including… read more here.
Keywords: upstream regulator; kinase domain; regulator autophagy; cancer ... See more keywords
A small RNA regulator of autophagy
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DOI: 10.1126/science.363.6431.1053-f
Abstract: Molecular Biology Autophagy serves an essential cellular-garbage disposal function. For example, the autophagy receptor p62 (or sequestosome-1) is needed for selective removal of intracellular pathogen material to the autophagosome for degradation. Notably, p62 must oligomerize… read more here.
Keywords: biology; small rna; rna regulator; regulator autophagy ... See more keywords