Regulating the Master Regulator: Controlling Ubiquitination by Thinking Outside the Active Site.
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DOI: 10.1021/acs.jmedchem.6b01346
Abstract: The labeling of proteins with ubiquitin/ubiquitin-like (Ubl) proteins is crucial for several physiological processes and in the onset of various diseases. Recently, targeting ubiquitin protein labeling has shifted toward the use of allosteric mechanisms over… read more here.
Keywords: regulating master; active site; site; master regulator ... See more keywords
UBTD1 is a mechano‐regulator controlling cancer aggressiveness
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DOI: 10.15252/embr.201846570
Abstract: Ubiquitin domain‐containing protein 1 (UBTD1) is highly evolutionary conserved and has been described to interact with E2 enzymes of the ubiquitin–proteasome system. However, its biological role and the functional significance of this interaction remain largely… read more here.
Keywords: ubtd1 mechano; mechano regulator; controlling cancer; regulator controlling ... See more keywords