Identification of a Master Regulator of Differentiation in Toxoplasma
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2019.12.013
Abstract: Summary Toxoplasma gondii chronically infects a quarter of the world’s population, and its recrudescence can cause life-threatening disease in immunocompromised individuals and recurrent ocular lesions in the immunocompetent. Acute-stage tachyzoites differentiate into chronic-stage bradyzoites, which… read more here.
Keywords: identification master; regulator differentiation; differentiation toxoplasma; toxoplasma ... See more keywords
NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.46551
Abstract: Squamous cell carcinomas (SCCs) account for the majority of cancer mortalities. Although TP63 is an established lineage-survival oncogene in SCCs, therapeutic strategies have not been developed to target TP63 or it’s downstream effectors. In this… read more here.
Keywords: critical regulator; regulator differentiation; nrg1 critical; cell ... See more keywords