PPT1 is a negative regulator of STING signaling in cancer cells and its inhibition reactivates immune surveillance in cold tumors.
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DOI: 10.1073/pnas.2514948122
Abstract: Immunotherapy modalities have revolutionized cancer treatment for a number of metastatic and treatment-refractory tumor types. Still, many malignancies that lack T cell infiltration and are termed immunologically "cold" fail to respond to these modalities. One… read more here.
Keywords: cancer; ppt1 negative; negative regulator; regulator sting ... See more keywords