Spatially conserved motifs in complement control protein domains determine functionality in regulators of complement activation-family proteins
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0529-9
Abstract: Regulation of complement activation in the host cells is mediated primarily by the regulators of complement activation (RCA) family proteins that are formed by tandemly repeating complement control protein (CCP) domains. Functional annotation of these… read more here.
Keywords: control protein; complement control; regulators complement; complement ... See more keywords
Tissue-targeted regulators of complement for amelioration of human disease: rationale and novel therapeutic strategies.
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DOI: 10.1093/jimmun/vkaf053
Abstract: The complement system is an essential part of innate immunity, and dysregulated complement is an underlying driver in many inflammatory and autoimmune diseases. Currently approved complement-focused therapeutics rely on systemic blockade of complement activation, but… read more here.
Keywords: regulators complement; tissue targeted; targeted regulators; complement amelioration ... See more keywords
Cross-species protection suggests Entamoeba histolytica trogocytosis enables complement resistance through the transfer of negative regulators of complement activation
Sign Up to like & getrecommendations! Published in 2024 at "Infection and Immunity"
DOI: 10.1128/iai.00220-25
Abstract: ABSTRACT Entamoeba histolytica is a major cause of diarrheal disease. E. histolytica trophozoites (“amoebae”) can invade the intestine and disseminate via the bloodstream, resisting complement lysis through unknown mechanisms. Amoebae kill human cells by performing… read more here.
Keywords: trogocytosis; regulators complement; lysis; complement activation ... See more keywords