Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives
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DOI: 10.1021/acs.jmedchem.1c01897
Abstract: In cystic fibrosis (CF), the deletion of phenylalanine 508 (F508del) in the CF transmembrane conductance regulator (CFTR) leads to misfolding and premature degradation of the mutant protein. These defects can be targeted with pharmacological agents… read more here.
Keywords: proteostasis regulators; proteostasis; fibrosis current; regulators cystic ... See more keywords