Neutrophils as regulators of the hematopoietic niche.
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DOI: 10.1182/blood-2018-10-844571
Abstract: The niche that supports hematopoietic stem and progenitor cells (HSPCs) in the bone marrow is a highly dynamic structure. It maintains core properties of HSPCs in the steady state, and modulates their proliferation and differentiation… read more here.
Keywords: immune; regulators hematopoietic; neutrophils regulators; hematopoietic niche ... See more keywords
Dysregulation of the TET family of epigenetic regulators in hematopoietic malignancies.
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DOI: 10.1182/blood.2019791475
Abstract: DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon silencing, genomic imprinting, X-chromosome inactivation and cancer. Cancer cells display highly dysregulated DNA methylation profiles characterized by global hypomethylation in conjunction with hypermethylation of promoter… read more here.
Keywords: epigenetic regulators; tet family; family epigenetic; dysregulation tet ... See more keywords