Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming
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DOI: 10.1016/j.arr.2018.02.004
Abstract: Regulatory role of Sirtuin 1 (SIRT1), one of the most extensively studied members of its kind in histone deacetylase family in governing multiple cellular fates, is predominantly linked to p53 activity. SIRT1 deacetylates p53 in… read more here.
Keywords: regulatory axis; role; cancer; p53 ... See more keywords
MYC regulation of glutamine–proline regulatory axis is key in luminal B breast cancer
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DOI: 10.1038/bjc.2017.387
Abstract: Background:Altered cellular metabolism is a hallmark of cancer and some are reliant on glutamine for sustained proliferation and survival. We hypothesise that the glutamine–proline regulatory axis has a key role in breast cancer (BC) in… read more here.
Keywords: glutamine proline; regulatory axis; proline regulatory; cancer ... See more keywords
Identification and Verification of Necroptosis-Related Gene Signature and Associated Regulatory Axis in Breast Cancer
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DOI: 10.3389/fgene.2022.842218
Abstract: Background: Breast invasive carcinoma (BRCA) is the second leading cause of malignancy death among women. Necroptosis is a newly discovered mechanism of cell death involved in the progression and prognosis of cancer. The role of… read more here.
Keywords: necroptosis related; brca; regulatory axis; signature ... See more keywords
Identification and Validation of Cuproptosis-Related Prognostic Signature and Associated Regulatory Axis in Uterine Corpus Endometrial Carcinoma
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DOI: 10.3389/fgene.2022.912037
Abstract: Background: Uterine corpus endometrial carcinoma (UCEC) is a common gynecological malignancy globally with high recurrence and mortality rates. Cuproptosis is a new type of programmed cell death involved in tumor cell proliferation and growth, angiogenesis,… read more here.
Keywords: regulatory axis; cuproptosis; related prognostic; prognostic signature ... See more keywords
Prognostic Characteristics of Immune-Related Genes and the Related Regulatory Axis in Patients With Stage N+M0 Breast Cancer
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DOI: 10.3389/fonc.2022.878219
Abstract: Breast cancer (BRCA) has the highest incidence rate among female tumours. The function of the immune system affects treatment efficacy and prognosis in patients with BRCA. However, the exact role of immune-related genes (IRGs) in… read more here.
Keywords: regulatory axis; patients stage; stage brca; stage ... See more keywords
Identification of Potential miRNA-mRNA Regulatory Axis of Intrahepatic cccDNA in Patients with Chronic Hepatitis B Virus Infection in the Grey Zone
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DOI: 10.5812/hepatmon-133782
Abstract: Background: Intrahepatic covalently closed circular DNA (cccDNA) plays a critical role in the life cycle of the hepatitis B virus (HBV). Growing evidence suggests that microRNAs (miRNAs) may regulate cccDNA expression and contribute to the… read more here.
Keywords: regulatory axis; mirna mrna; hepatitis; intrahepatic cccdna ... See more keywords