Inhibins regulate peripheral regulatory T cell induction through modulation of dendritic cell function
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DOI: 10.1002/2211-5463.12555
Abstract: We have previously reported that the absence of inhibins results in impaired dendritic cell (DC) maturation and function, leading to decreased T cell activation and diminished delayed‐type hypersensitivity responses. Here, we investigated the role of… read more here.
Keywords: regulatory cell; induction; function; cell ... See more keywords
Regulatory T‐cell‐derived interleukin‐15 shapes cytotoxic T cell memory
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202250238
Abstract: It is well known that regulatory T‐cells (Tregs) are required to prevent autoimmunity, but they may also have some less‐well understood immune‐stimulatory effects. In particular, in CD8+ T‐cell responses Tregs select high‐affinity clones upon priming… read more here.
Keywords: cell; regulatory cell; cell memory; memory ... See more keywords
Treatment of type 1 diabetes by regulatory T‐cell infusion via regulating the expression of inflammatory cytokines
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DOI: 10.1002/jcb.27875
Abstract: To explore the role and molecular mechanism of regulatory T (Treg) cells in type 1 diabetes (T1D). read more here.
Keywords: treatment type; regulatory cell; diabetes regulatory; type diabetes ... See more keywords
Differential profile of activated regulatory T cell subsets and microRNAs in tolerant liver transplant recipients
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DOI: 10.1002/lt.24691
Abstract: Regulatory T cells (Tregs) play a potential role in operational tolerance in liver transplantation (LT) patients, and microRNAs (miRNAs) are known to be involved in immunological responses and tolerance. Thus, we analyzed the implication of… read more here.
Keywords: regulatory cell; tolerance; liver; tol ... See more keywords
Monitoring and Modulation of Inducible Foxp3+ Regulatory T-Cell Differentiation in the Lymph Nodes Draining the Small Intestine and Colon.
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DOI: 10.1007/978-1-4939-6786-5_16
Abstract: The mucosa-draining lymphoid tissue favors differentiation of inducible Foxp3+ regulatory T cells. Adoptive transfer of T-cell receptor (TCR) transgenic (Tg) T cells is a powerful tool to study antigen-specific regulatory T-cell differentiation in lymphoid tissues… read more here.
Keywords: lymph nodes; cell differentiation; regulatory cell; foxp3 regulatory ... See more keywords
Successful elevation of circulating acetate and propionate by dietary modulation does not alter T-regulatory cell or cytokine profiles in healthy humans: a pilot study
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nutrition"
DOI: 10.1007/s00394-019-02113-2
Abstract: Increased circulating concentrations of short-chain fatty acids (SCFA) achieved by ingestion of high-fibre diets is associated with anti-inflammatory effects through promotion of FoxP3+ regulatory T(reg) cells in mouse models. This study aimed to determine whether… read more here.
Keywords: acetate propionate; day; regulatory cell; study ... See more keywords
A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells
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DOI: 10.1016/j.cell.2021.05.028
Abstract: A fraction of mature T cells can be activated by peripheral self-antigens, potentially eliciting host autoimmunity. We investigated homeostatic control of self-activated T cells within unperturbed tissue environments by combining high-resolution multiplexed and volumetric imaging with computational… read more here.
Keywords: regulatory cell; local regulatory; feedback; activated cells ... See more keywords
Epigenetic and transcriptional analysis supports human regulatory T cell commitment at the CD4+CD8+ thymocyte stage.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2019.104026
Abstract: The natural CD25+ FOXP3+ regulatory T cell (Treg) population is generated as a distinct lineage in the thymus, but the details of Treg development in humans remain unclear, and the timing of Treg commitment is… read more here.
Keywords: cd4 cd8; regulatory cell; commitment; stage ... See more keywords
Regulatory T cell therapy: Current and future design perspectives.
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DOI: 10.1016/j.cellimm.2020.104193
Abstract: Regulatory T cells (Tregs) maintain immune equilibrium by suppressing immune responses through various multistep contact dependent and independent mechanisms. Cellular therapy using polyclonal Tregs in transplantation and autoimmune diseases has shown promise in preclinical models… read more here.
Keywords: regulatory cell; cell therapy; therapy; car ... See more keywords
Human Fc Receptor-like 3 Inhibits Regulatory T Cell Function and Binds Secretory IgA.
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DOI: 10.1016/j.celrep.2019.12.099
Abstract: Human Fc receptor-like 3 (FCRL3) is an orphan receptor expressed by lymphocytes, including regulatory T cells. FCRL3 is implicated in several autoimmune diseases; however, its function on regulatory T cells is unknown. We discovered that FCRL3 stimulation… read more here.
Keywords: human receptor; receptor like; regulatory cell; secretory iga ... See more keywords
Characteristics of regulatory T-cell populations before and after Ty21a typhoid vaccination in children and adults.
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DOI: 10.1016/j.clim.2019.04.002
Abstract: Typhoid fever, caused by the pathogen Salmonella enterica serovar Typhi (S. Typhi), is a serious global health concern. Challenge studies with wild type S. Typhi identified associations between gut-homing regulatory T cells (Treg) and development… read more here.
Keywords: typhi; regulatory cell; characteristics regulatory; ty21a vaccination ... See more keywords