Articles with "regulatory cells" as a keyword



In Vivo Accumulation of Regulatory T Cells Using Eliglustat‐Loaded Cryogels

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Published in 2025 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202501529

Abstract: Regulatory T cells (Tregs) maintain immune homeostasis and their adoptive transfer is being widely explored to mitigate inflammatory and autoimmune conditions. Here a biomaterial is developed to accumulate Tregs at a specific anatomic location to… read more here.

Keywords: loaded cryogels; eliglustat loaded; regulatory cells; vivo accumulation ... See more keywords

Regulatory T‐Cells During Pregnancy Relate to Women's Own Childhood History of Microbial Exposure

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Published in 2025 at "American Journal of Human Biology"

DOI: 10.1002/ajhb.70013

Abstract: Previous studies found that children with siblings, farm residence, and other proxies of greater microbial contacts had lower rates of hyper‐responsive immune disorders. Yet, scientific debate persists regarding whether the human immune system is educated… read more here.

Keywords: history; regulatory cells; microbial exposures; pregnancy relate ... See more keywords

Investigation on the regulatory T cells signature and relevant Foxp3/STAT3 axis in esophageal cancer

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Published in 2022 at "Cancer Medicine"

DOI: 10.1002/cam4.5194

Abstract: Regulatory T cells (Tregs) have an important role in accelerating the immunosuppression of tumor. Tregs regulation is a hopeful strategy to improve the dismal prognosis of Esophageal cancer (EC), while its mechanisms have not yet… read more here.

Keywords: esophageal cancer; regulatory cells; cells signature; investigation regulatory ... See more keywords

A stratified therapeutic model incorporated with studies on regulatory B cells for elderly patients with newly diagnosed multiple myeloma

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Published in 2022 at "Cancer Medicine"

DOI: 10.1002/cam4.5228

Abstract: Despite the availability of new agents, elderly patients with multiple myeloma (MM) usually present with poor outcomes due to the heterogeneity of disease conditions, especially immune deficiency. Regulatory B cells (Bregs) can be involved in… read more here.

Keywords: stratified therapeutic; elderly patients; regulatory cells; therapeutic model ... See more keywords

A simple twist of phosphate: Immunological synapse formation and T cell receptor signaling outcome in regulatory T cells

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Published in 2017 at "European Journal of Immunology"

DOI: 10.1002/eji.201747359

Abstract: Signaling through the T cell receptor (TCR) regulates T cell homeostasis and effector functions. However, a full accounting of the TCR‐coupled signaling networks and how their interplay determines specific functional outcomes remains elusive. Of particular… read more here.

Keywords: treg; regulatory cells; cell receptor; cell ... See more keywords

Regulatory T cells are required for normal and activin‐promoted wound repair in mice

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Published in 2018 at "European Journal of Immunology"

DOI: 10.1002/eji.201747395

Abstract: Healing of skin wounds is orchestrated by various types of immune cells, but little is known about the role of FoxP3+ regulatory T cells (Tregs) in this process. Here, we determined if Tregs are important… read more here.

Keywords: wound repair; regulatory cells; required normal; cells required ... See more keywords
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SOCS3 is a suppressor of γc cytokine signaling and constrains generation of murine Foxp3+ regulatory T cells

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Published in 2020 at "European Journal of Immunology"

DOI: 10.1002/eji.201948307

Abstract: SOCS3 is a cytosolic inhibitor of cytokine signaling that suppresses the activation of cytokine receptor‐associated JAK kinases. Mechanistically, SOCS3 is recruited to a site in the cytokine receptors known as the SOCS3‐interaction motif, and then… read more here.

Keywords: cytokine; socs3; foxp3 regulatory; cytokine signaling ... See more keywords
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Hyperlipidemia induced metabolic changes in regulatory T cells result in altered function.

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Published in 2021 at "European journal of immunology"

DOI: 10.1002/eji.202049149

Abstract: Regulatory T cells (Tregs) play a critical role in maintaining self-tolerance and controlling inflammation. However, physiologically relevant conditions that alter Treg function and drive disease pathogenesis are poorly understood and few have been defined. We… read more here.

Keywords: hyperlipidemia; metabolism; induction hyperlipidemia; regulatory cells ... See more keywords

MALT1 protease function in regulatory T cells induces MYC activity to promote mitochondrial function and cellular expansion.

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Published in 2021 at "European journal of immunology"

DOI: 10.1002/eji.202149355

Abstract: Regulatory T cells (Tregs) are essential for the inhibition of immunity and the maintenance of tissue homeostasis. Signals from the T cell antigen receptor (TCR) are critical for early Treg development, their expansion and inhibitory… read more here.

Keywords: expansion; malt1 protease; regulatory cells; function ... See more keywords

STAT6 controls the stability and suppressive function of regulatory T cells

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Published in 2023 at "European Journal of Immunology"

DOI: 10.1002/eji.202250128

Abstract: Signal transducer and activator of transcription 6 (STAT6) promotes tumorigenesis by decreasing the Forkhead box P3+ (Foxp3+) cell frequency allowing for the infiltration of inflammatory cells during the early stages of colitis‐associated cancer (CAC). In… read more here.

Keywords: regulatory cells; stat6 controls; stability suppressive; stat6 ... See more keywords

Decoding the potential role of regulatory T cells in sepsis‐induced immunosuppression

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Published in 2024 at "European Journal of Immunology"

DOI: 10.1002/eji.202350730

Abstract: Sepsis, a multiorgan dysfunction with high incidence and mortality, is caused by an imbalanced host‐to‐infection immune response. Organ‐support therapy improves the early survival rate of sepsis patients. In the long term, those who survive the… read more here.

Keywords: regulatory cells; role; induced immunosuppression; sepsis induced ... See more keywords