Investigation on the regulatory T cells signature and relevant Foxp3/STAT3 axis in esophageal cancer
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DOI: 10.1002/cam4.5194
Abstract: Regulatory T cells (Tregs) have an important role in accelerating the immunosuppression of tumor. Tregs regulation is a hopeful strategy to improve the dismal prognosis of Esophageal cancer (EC), while its mechanisms have not yet… read more here.
Keywords: esophageal cancer; regulatory cells; cells signature; investigation regulatory ... See more keywords
A stratified therapeutic model incorporated with studies on regulatory B cells for elderly patients with newly diagnosed multiple myeloma
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DOI: 10.1002/cam4.5228
Abstract: Despite the availability of new agents, elderly patients with multiple myeloma (MM) usually present with poor outcomes due to the heterogeneity of disease conditions, especially immune deficiency. Regulatory B cells (Bregs) can be involved in… read more here.
Keywords: stratified therapeutic; elderly patients; regulatory cells; therapeutic model ... See more keywords
A simple twist of phosphate: Immunological synapse formation and T cell receptor signaling outcome in regulatory T cells
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201747359
Abstract: Signaling through the T cell receptor (TCR) regulates T cell homeostasis and effector functions. However, a full accounting of the TCR‐coupled signaling networks and how their interplay determines specific functional outcomes remains elusive. Of particular… read more here.
Keywords: treg; regulatory cells; cell receptor; cell ... See more keywords
Regulatory T cells are required for normal and activin‐promoted wound repair in mice
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747395
Abstract: Healing of skin wounds is orchestrated by various types of immune cells, but little is known about the role of FoxP3+ regulatory T cells (Tregs) in this process. Here, we determined if Tregs are important… read more here.
Keywords: wound repair; regulatory cells; required normal; cells required ... See more keywords
SOCS3 is a suppressor of γc cytokine signaling and constrains generation of murine Foxp3+ regulatory T cells
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.201948307
Abstract: SOCS3 is a cytosolic inhibitor of cytokine signaling that suppresses the activation of cytokine receptor‐associated JAK kinases. Mechanistically, SOCS3 is recruited to a site in the cytokine receptors known as the SOCS3‐interaction motif, and then… read more here.
Keywords: cytokine; socs3; foxp3 regulatory; cytokine signaling ... See more keywords
Hyperlipidemia induced metabolic changes in regulatory T cells result in altered function.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of immunology"
DOI: 10.1002/eji.202049149
Abstract: Regulatory T cells (Tregs) play a critical role in maintaining self-tolerance and controlling inflammation. However, physiologically relevant conditions that alter Treg function and drive disease pathogenesis are poorly understood and few have been defined. We… read more here.
Keywords: hyperlipidemia; metabolism; induction hyperlipidemia; regulatory cells ... See more keywords
MALT1 protease function in regulatory T cells induces MYC activity to promote mitochondrial function and cellular expansion.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of immunology"
DOI: 10.1002/eji.202149355
Abstract: Regulatory T cells (Tregs) are essential for the inhibition of immunity and the maintenance of tissue homeostasis. Signals from the T cell antigen receptor (TCR) are critical for early Treg development, their expansion and inhibitory… read more here.
Keywords: expansion; malt1 protease; regulatory cells; function ... See more keywords
STAT6 controls the stability and suppressive function of regulatory T cells
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202250128
Abstract: Signal transducer and activator of transcription 6 (STAT6) promotes tumorigenesis by decreasing the Forkhead box P3+ (Foxp3+) cell frequency allowing for the infiltration of inflammatory cells during the early stages of colitis‐associated cancer (CAC). In… read more here.
Keywords: regulatory cells; stat6 controls; stability suppressive; stat6 ... See more keywords
Depletion of Foxp3+ regulatory T cells but not the absence of CD19+IL‐10+ regulatory B cells hinders tumor growth in a para‐orthotopic neuroblastoma mouse model
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DOI: 10.1002/ijc.34262
Abstract: Adaptive immune cells with regulatory function reportedly mediate immune escape in a variety of tumors. Little is known regarding the relevance of the most prominent regulatory cell populations, namely Foxp3+ T regulatory cells (Tregs) and… read more here.
Keywords: tumor growth; regulatory cells; foxp3 regulatory; cd19 regulatory ... See more keywords
Exosomes derived from regulatory T cells ameliorate acute myocardial infarction by promoting macrophage M2 polarization
Sign Up to like & getrecommendations! Published in 2020 at "IUBMB Life"
DOI: 10.1002/iub.2364
Abstract: Acute myocardial infarction (AMI) is a serious ischemic heart disease. Regulatory T cells (Tregs) participate in AMI. This article aims to investigate the mechanism of action of Tregs in AMI. We constructed AMI mouse model.… read more here.
Keywords: myocardial infarction; exosomes derived; regulatory cells; promoting macrophage ... See more keywords
Curcumin converts Foxp3+ regulatory T cells to T helper 1 cells in patients with lung cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26302
Abstract: The regulatory T cells (Treg) play an important role in the tumor tolerance. The methods to regulate the Treg population in cancer‐bearing hosts are limited currently. The effect of curcumin on inhibiting cancer has been… read more here.
Keywords: th1 cells; regulatory cells; helper cells; lung cancer ... See more keywords