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Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202501529
Abstract: Regulatory T cells (Tregs) maintain immune homeostasis and their adoptive transfer is being widely explored to mitigate inflammatory and autoimmune conditions. Here a biomaterial is developed to accumulate Tregs at a specific anatomic location to…
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Keywords:
loaded cryogels;
eliglustat loaded;
regulatory cells;
vivo accumulation ... See more keywords
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Published in 2025 at "American Journal of Human Biology"
DOI: 10.1002/ajhb.70013
Abstract: Previous studies found that children with siblings, farm residence, and other proxies of greater microbial contacts had lower rates of hyper‐responsive immune disorders. Yet, scientific debate persists regarding whether the human immune system is educated…
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Keywords:
history;
regulatory cells;
microbial exposures;
pregnancy relate ... See more keywords
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Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5194
Abstract: Regulatory T cells (Tregs) have an important role in accelerating the immunosuppression of tumor. Tregs regulation is a hopeful strategy to improve the dismal prognosis of Esophageal cancer (EC), while its mechanisms have not yet…
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Keywords:
esophageal cancer;
regulatory cells;
cells signature;
investigation regulatory ... See more keywords
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Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5228
Abstract: Despite the availability of new agents, elderly patients with multiple myeloma (MM) usually present with poor outcomes due to the heterogeneity of disease conditions, especially immune deficiency. Regulatory B cells (Bregs) can be involved in…
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Keywords:
stratified therapeutic;
elderly patients;
regulatory cells;
therapeutic model ... See more keywords
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Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201747359
Abstract: Signaling through the T cell receptor (TCR) regulates T cell homeostasis and effector functions. However, a full accounting of the TCR‐coupled signaling networks and how their interplay determines specific functional outcomes remains elusive. Of particular…
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Keywords:
treg;
regulatory cells;
cell receptor;
cell ... See more keywords
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Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747395
Abstract: Healing of skin wounds is orchestrated by various types of immune cells, but little is known about the role of FoxP3+ regulatory T cells (Tregs) in this process. Here, we determined if Tregs are important…
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Keywords:
wound repair;
regulatory cells;
required normal;
cells required ... See more keywords
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Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.201948307
Abstract: SOCS3 is a cytosolic inhibitor of cytokine signaling that suppresses the activation of cytokine receptor‐associated JAK kinases. Mechanistically, SOCS3 is recruited to a site in the cytokine receptors known as the SOCS3‐interaction motif, and then…
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Keywords:
cytokine;
socs3;
foxp3 regulatory;
cytokine signaling ... See more keywords
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Published in 2021 at "European journal of immunology"
DOI: 10.1002/eji.202049149
Abstract: Regulatory T cells (Tregs) play a critical role in maintaining self-tolerance and controlling inflammation. However, physiologically relevant conditions that alter Treg function and drive disease pathogenesis are poorly understood and few have been defined. We…
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Keywords:
hyperlipidemia;
metabolism;
induction hyperlipidemia;
regulatory cells ... See more keywords
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Published in 2021 at "European journal of immunology"
DOI: 10.1002/eji.202149355
Abstract: Regulatory T cells (Tregs) are essential for the inhibition of immunity and the maintenance of tissue homeostasis. Signals from the T cell antigen receptor (TCR) are critical for early Treg development, their expansion and inhibitory…
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Keywords:
expansion;
malt1 protease;
regulatory cells;
function ... See more keywords
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Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202250128
Abstract: Signal transducer and activator of transcription 6 (STAT6) promotes tumorigenesis by decreasing the Forkhead box P3+ (Foxp3+) cell frequency allowing for the infiltration of inflammatory cells during the early stages of colitis‐associated cancer (CAC). In…
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Keywords:
regulatory cells;
stat6 controls;
stability suppressive;
stat6 ... See more keywords
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Published in 2024 at "European Journal of Immunology"
DOI: 10.1002/eji.202350730
Abstract: Sepsis, a multiorgan dysfunction with high incidence and mortality, is caused by an imbalanced host‐to‐infection immune response. Organ‐support therapy improves the early survival rate of sepsis patients. In the long term, those who survive the…
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Keywords:
regulatory cells;
role;
induced immunosuppression;
sepsis induced ... See more keywords