A regulatory circuit of two lncRNAs and a master regulator directs cell fate in yeast
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03213-z
Abstract: Transcription of long noncoding RNAs (lncRNAs) regulates local gene expression in eukaryotes. Many examples of how a single lncRNA controls the expression of an adjacent or nearby protein-coding gene have been described. Here we examine… read more here.
Keywords: circuit; regulatory circuit; master regulator; transcription ... See more keywords
A lysosomal regulatory circuit essential for the development and function of microglia
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abp8321
Abstract: As the primary phagocytic cells of the central nervous system, microglia exquisitely regulate their lysosomal activity to facilitate brain development and homeostasis. However, mechanisms that coordinate lysosomal activity with microglia development, chemotaxis, and function remain… read more here.
Keywords: function; development; regulatory circuit; lysosomal regulatory ... See more keywords
Proteomic profiling of the monothiol glutaredoxin Grx3 reveals its global role in the regulation of iron dependent processes
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008881
Abstract: Iron is an essential nutrient required as a cofactor for many biological processes. As a fungal commensal-pathogen of humans, Candida albicans encounters a range of bioavailable iron levels in the human host and maintains homeostasis… read more here.
Keywords: iron dependent; grx3; regulatory circuit; regulation iron ... See more keywords