ODE-Based Modeling of Complex Regulatory Circuits.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7125-1_20
Abstract: Transcriptional regulatory circuits are often complex, consisting of many components and regulatory interactions. Mathematical modeling is an important tool for understanding the behavior of these circuits, and identifying gaps in our understanding of gene regulation.… read more here.
Keywords: ode based; complex regulatory; regulatory circuits; based modeling ... See more keywords
Virtual Parts Repository 2: Model-Driven Design of Genetic Regulatory Circuits.
Sign Up to like & getrecommendations! Published in 2021 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.1c00157
Abstract: Engineering genetic regulatory circuits is key to the creation of biological applications that are responsive to environmental changes. Computational models can assist in understanding especially large and complex circuits for which manual analysis is infeasible,… read more here.
Keywords: genetic regulatory; regulatory circuits; model driven; model ... See more keywords
Regulatory circuits controlling Spx levels in Streptococcus mutans
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DOI: 10.1111/mmi.14499
Abstract: Spx is a major regulator of stress responses in Firmicutes. In Streptococcus mutans, two Spx homologues, SpxA1 and SpxA2, were identified as mediators of oxidative stress responses but the regulatory circuits controlling their levels and… read more here.
Keywords: spxa2; spx; regulatory circuits; stress ... See more keywords
PO-194 Identification of regulatory circuits specific to breast cancer development by enrichment based circuit finder
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.712
Abstract: Introduction Gene expression mechanism is regulated by transcriptional factors (TF) in transcriptional level and by miRNAs in post-transcriptional level. Transcription of mRNAs and miRNAs are controlled by TFs and TF expressions are regulated by miRNAs.… read more here.
Keywords: analysis; breast cancer; regulatory circuits; cancer ... See more keywords
Enhancer Predictions and Genome-Wide Regulatory Circuits.
Sign Up to like & getrecommendations! Published in 2020 at "Annual review of genomics and human genetics"
DOI: 10.1146/annurev-genom-121719-010946
Abstract: Spatiotemporal control of gene expression during development requires orchestrated activities of numerous enhancers, which are cis-regulatory DNA sequences that, when bound by transcription factors, support selective activation or repression of associated genes. Proper activation of… read more here.
Keywords: genome wide; predictions genome; enhancer predictions; wide regulatory ... See more keywords
Gene Regulatory Circuits in Innate and Adaptive Immune Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of immunology"
DOI: 10.1146/annurev-immunol-101320-025949
Abstract: Cell identity and function largely rely on the programming of transcriptomes during development and differentiation. Signature gene expression programs are orchestrated by regulatory circuits consisting of cis-acting promoters and enhancers, which respond to a plethora… read more here.
Keywords: gene regulatory; regulatory circuits; innate adaptive; immune cells ... See more keywords