Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution
Sign Up to like & getrecommendations! Published in 2021 at "Nature genetics"
DOI: 10.1038/s41588-021-00804-3
Abstract: Gene regulatory divergence is thought to play a central role in determining human-specific traits. However, our ability to link divergent regulation to divergent phenotypes is limited. Here, we utilized human-chimpanzee hybrid induced pluripotent stem cells… read more here.
Keywords: hedgehog signaling; regulatory divergence; human chimpanzee; chimpanzee fused ... See more keywords
Regulatory Divergence as a Mechanism for X-Autosome Incompatibilities in Caenorhabditis Nematodes
Sign Up to like & getrecommendations! Published in 2022 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evad055
Abstract: The world’s astounding biodiversity results from speciation, the process of formation of distinct species. Hybrids between species often have reduced fitness due to negative epistatic interactions between divergent genetic factors, as each lineage accumulated substitutions… read more here.
Keywords: autosome incompatibilities; regulatory divergence; misexpression; divergence ... See more keywords
Evolution of Spatial and Temporal cis-Regulatory Divergence in Sticklebacks
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msad034
Abstract: Abstract Cis-regulatory changes are thought to play a major role in adaptation. Threespine sticklebacks have repeatedly colonized freshwater habitats in the Northern Hemisphere, where they have evolved a suite of phenotypes that distinguish them from… read more here.
Keywords: role; regulatory divergence; cis regulatory; cis ... See more keywords
Unraveling the start element and regulatory divergence of core promoters across the domain bacteria
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf1310
Abstract: Core promoters comprise multiple elements whose interaction with RNA polymerase initiates transcription. Despite decades of research, substantial sequence and length variation of promoter elements has hindered efforts to elucidate their function and the evolutionary diversity… read more here.
Keywords: promoter; element; regulatory divergence; core promoters ... See more keywords