PKU mutation p.G46S prevents the stereospecific binding of l‐phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain
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DOI: 10.1002/2211-5463.12175
Abstract: Mammalian phenylalanine hydroxylase (PAH) has a potential allosteric regulatory binding site for l‐phenylalanine (l‐Phe), in addition to its catalytic site. This arrangement is supported by a crystal structure of a homodimeric truncated form of the… read more here.
Keywords: hpah; regulatory domain; phenylalanine; phenylalanine hydroxylase ... See more keywords
Binding of the regulatory domain of MutL to the sliding β-clamp is species specific
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DOI: 10.1093/nar/gkz115
Abstract: Abstract The β-clamp is a protein hub central to DNA replication and fork management. Proteins interacting with the β-clamp harbor a conserved clamp-binding motif that is often found in extended regions. Therefore, clamp interactions have… read more here.
Keywords: clamp binding; regulatory domain; clamp; mutl ... See more keywords
The Peptidyl-Prolyl cis-trans isomerase, Pin1, associates with Protein Kinase C θ via a critical Phospho-Thr-Pro motif in the V3 regulatory domain
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DOI: 10.3389/fimmu.2023.1126464
Abstract: Protein kinase C-θ (PKCθ) is a member of the novel PKC subfamily known for its selective and predominant expression in T lymphocytes where it regulates essential functions required for T cell activation and proliferation. Our… read more here.
Keywords: regulatory domain; pin1 pkc; pin1; pro motif ... See more keywords