The importance of considering regulatory domains in genome-wide analyses – the nearest gene is often wrong!
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DOI: 10.1242/bio.059091
Abstract: ABSTRACT The expression of a large number of genes is regulated by regulatory elements that are located far away from their promoters. Identifying which gene is the target of a specific regulatory element or is… read more here.
Keywords: nearest gene; genome wide; importance considering; regulatory domains ... See more keywords
The regulatory domains of the lipid exporter ABCA1 form domain swapped latches
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DOI: 10.1371/journal.pone.0262746
Abstract: ABCA1 and ABCA4 are enigmatic because they transport substrates in opposite directions yet share >50% amino acid identity. ABCA4 imports lipid conjugates but ABCA1 exports lipids. Both hydrolyze ATP to drive transport, and both contain… read more here.
Keywords: domain swapped; exporter; domain; regulatory domains ... See more keywords