Inhibition of the sterol regulatory element‐binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.29018
Abstract: Obesity is a critical risk factor for hepatocellular carcinoma (HCC). However, it remains unknown whether inhibition of de novo lipid biosynthesis can suppress HCC. In this study, we blocked the sterol regulatory element‐binding protein (SREBP)… read more here.
Keywords: hepatocellular carcinoma; inhibition; regulatory element; pathway ... See more keywords
HBsAg mRNA degradation induced by a dihydroquinolizinone compound depends on the HBV posttranscriptional regulatory element
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.11.009
Abstract: ABSTRACT In pursuit of novel therapeutics targeting the hepatitis B virus (HBV) infection, we evaluated a dihydroquinolizinone compound (DHQ‐1) that in the nanomolar range reduced the production of virion and surface protein (HBsAg) in tissue… read more here.
Keywords: rna; hbv; regulatory element; hbsag mrna ... See more keywords
Regulatory roles of sterol regulatory element-binding protein (SREBP) on lipid metabolism in marine invertebrate Chlamys nobilis.
Sign Up to like & getrecommendations! Published in 2018 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2018.03.023
Abstract: Abstract Sterol regulatory element-binding protein (SREBP) has mainly been studied in vertebrates in which lipogenesis is regulated in both liver and adipose tissue. There is, however, a paucity of information on bivalves, in which lipogenesis… read more here.
Keywords: regulatory element; srebp; protein srebp; binding protein ... See more keywords
Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.02.006
Abstract: Conditions of the tumor microenvironment, such as hypoxia and nutrient starvation, play critical roles in cancer progression. However, the role of acidic extracellular pH in cancer progression is not studied as extensively as that of hypoxia.… read more here.
Keywords: regulatory element; element binding; sterol regulatory; cancer ... See more keywords
Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09152-7
Abstract: Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for cholesterol, fatty acid, triacylglycerol and phospholipid synthesis. In… read more here.
Keywords: metabolism; regulatory element; mechanical cues; sterol regulatory ... See more keywords
High-throughput identification of human SNPs affecting regulatory element activity
Sign Up to like & getrecommendations! Published in 2019 at "Nature genetics"
DOI: 10.1038/s41588-019-0455-2
Abstract: Most of the millions of SNPs in the human genome are non-coding, and many overlap with putative regulatory elements. Genome-wide association studies (GWAS) have linked many of these SNPs to human traits or to gene… read more here.
Keywords: element activity; snps; throughput; regulatory element ... See more keywords
HALPER facilitates the identification of regulatory element orthologs across species
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa493
Abstract: SUMMARY Diverse traits have evolved through cis-regulatory changes in genome sequence that influence the magnitude, timing, and cell type-specificity of gene expression. Advances in high-throughput sequencing and regulatory genomics have led to the identification of… read more here.
Keywords: regulatory element; element orthologs; halper facilitates; identification regulatory ... See more keywords
DCDC2 READ1 regulatory element: how temporal processing differences may shape language
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the Royal Society B: Biological Sciences"
DOI: 10.1098/rspb.2019.2712
Abstract: Classic linguistic theory ascribes language change and diversity to population migrations, conquests, and geographical isolation, with the assumption that human populations have equivalent language processing abilities. We hypothesize that spectral and temporal characteristics make some… read more here.
Keywords: element temporal; processing; read1 regulatory; regulatory element ... See more keywords
Sterol regulatory element binding protein‐1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer
Sign Up to like & getrecommendations! Published in 2017 at "Acta Obstetricia et Gynecologica Scandinavica"
DOI: 10.1111/aogs.13106
Abstract: Women with polycystic ovary syndrome have a three‐fold higher risk of endometrial cancer. Insulin resistance and hyperlipidemia may be pertinent factors in the pathogenesis of both conditions. The aim of this study was to investigate… read more here.
Keywords: polycystic ovary; regulatory element; endometrial cancer; ovary syndrome ... See more keywords
A novel B allele with c.28 + 5885C>T substitution in the erythroid cell–specific regulatory element identified in an individual with phenotype B3
Sign Up to like & getrecommendations! Published in 2017 at "Transfusion"
DOI: 10.1111/trf.14064
Abstract: The ABO blood group system is the most clinically important in blood transfusion. The decreased expression levels of A or B antigens of the ABO subtype often present difficulties in blood typing and cross-matching for… read more here.
Keywords: erythroid cell; regulatory element; element identified; substitution ... See more keywords
MON-108 Dihydrotestosterone Lowers Cytosolic Sterol Regulatory Element-Binding Protein-1 in Adipose Tissue from Female Mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-mon-108
Abstract: Abstract Abstract: Hyperandrogenemia (HA) and insulin resistance (IR) are hallmarks of polycystic ovary syndrome (PCOS), a common endocrine disorder that affects roughly 1 in 5 women, according to the Rotterdam criteria. These hallmarks are also… read more here.
Keywords: mice; sterol regulatory; regulatory element; low dose ... See more keywords