Cloning of the promoter of rice brown planthopper feeding-inducible gene OsTPS31 and identification of related cis-regulatory elements.
Sign Up to like & getrecommendations! Published in 2023 at "Pest management science"
DOI: 10.1002/ps.7356
Abstract: BACKGROUND Brown planthopper (BPH; Nilaparvata lugens) is one of the most serious pests of rice in the world. Insect-resistant genetic engineering is a very effective technology to control BPH. The promoters and cis-regulatory elements inducible… read more here.
Keywords: promoter; cis regulatory; rice; regulatory elements ... See more keywords
RNA thermometers and other regulatory elements: Diversity and importance in bacterial pathogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1711
Abstract: Survival of microorganisms depends to a large extent on environmental conditions and the occupied host. By adopting specific strategies, microorganisms can thrive in the surrounding environment and, at the same time, preserve their viability. Evading… read more here.
Keywords: elements diversity; thermometers regulatory; rna; importance ... See more keywords
Deletion of Regulatory Elements with All-in-One CRISPR-Cas9 Vectors.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1597-3_18
Abstract: Loss-of-function experiments are essential for the functional investigation of cis-regulatory elements (CREs), such as transcriptional enhancers. This can be achieved with CRISPR-Cas9 using pairs of single guide RNAs (sgRNAs) to target the flanking regions of… read more here.
Keywords: crispr cas9; deletion regulatory; one crispr; regulatory elements ... See more keywords
Dysregulation of Cis-Regulatory Elements in Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Epigenetics"
DOI: 10.1007/978-981-13-8958-0_8
Abstract: Cis-regulatory elements (CREs) are DNA sequences in the genome that regulate gene expression through their interaction with transcription factors and the transcription pre-initiation complex. These elements control the expression of genes that define the identity… read more here.
Keywords: dysregulation; dysregulation cis; expression; cis regulatory ... See more keywords
CRISPR-based strategies for studying regulatory elements and chromatin structure in mammalian gene control
Sign Up to like & getrecommendations! Published in 2017 at "Mammalian Genome"
DOI: 10.1007/s00335-017-9727-2
Abstract: The development of high-throughput methods has enabled the genome-wide identification of putative regulatory elements in a wide variety of mammalian cells at an unprecedented resolution. Extensive genomic studies have revealed the important role of regulatory… read more here.
Keywords: based strategies; crispr based; chromatin; strategies studying ... See more keywords
Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.01.109
Abstract: RET finger protein (RFP) forms a complex with histone deacetylase 1, resulting in aberrant deacetylation of H3K27ac and dysregulation of cis-regulatory elements. We evaluated the modulatory effects of RFP knockdown on cis-regulatory elements, gene expression,… read more here.
Keywords: glioblastoma; ret finger; cis regulatory; finger protein ... See more keywords
TooManyPeaks identifies drug-resistant-specific regulatory elements from single-cell leukemic epigenomes
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109575
Abstract: SUMMARY Emerging single-cell epigenomic assays are used to investigate the heterogeneity of chromatin activity and its function. However, identifying cells with distinct regulatory elements and clearly visualizing their relationships remains challenging. To this end, we… read more here.
Keywords: single cell; drug; drug resistant; cell ... See more keywords
Advances of DNase-seq for mapping active gene regulatory elements across the genome in animals.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.05.033
Abstract: Expression of the eukaryotic genome is a highly complex and tightly regulated process, and its regulation depends on interactions among cis-acting elements and transcription factors. Identification of active gene regulatory elements is key to understanding… read more here.
Keywords: advances dnase; gene regulatory; active gene; genome ... See more keywords
Deciphering the Gene Regulatory Landscape Encoded in DNA Biophysical Features
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.10.055
Abstract: Summary Gene regulation in higher organisms involves a sophisticated interplay between genetic and epigenetic mechanisms. Despite advances, the logic in selective usage of certain genomic regions as regulatory elements remains unclear. Here we show that… read more here.
Keywords: gene regulatory; landscape; regulatory landscape; gene ... See more keywords
Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.12.027
Abstract: A comprehensive catalog of cancer driver mutations is essential for understanding tumorigenesis and developing therapies. Exome-sequencing studies have mapped many protein-coding drivers, yet few non-coding drivers are known because genome-wide discovery is challenging. We developed… read more here.
Keywords: cancer driver; long range; cancer; driver mutations ... See more keywords
Novel cis-regulatory elements as synthetic promoters to drive recombinant protein expression from the Chlamydomonas reinhardtii nuclear genome.
Sign Up to like & getrecommendations! Published in 2022 at "New biotechnology"
DOI: 10.1016/j.nbt.2022.01.001
Abstract: Eukaryotic green microalgae represent a sustainable, photosynthetic biotechnology platform for generating high-value products. The model green alga Chlamydomonas reinhardtii has already been used to generate high value bioproducts such as recombinant proteins and terpenoids. However,… read more here.
Keywords: regulatory elements; expression; cis regulatory; protein expression ... See more keywords