Hepatic Interferon Regulatory Factor 6 Alleviates Liver Steatosis and Metabolic Disorder by Transcriptionally Suppressing Peroxisome Proliferator‐Activated Receptor γ in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30559
Abstract: Nonalcoholic fatty liver disease (NAFLD) has become a worldwide epidemic. A large and growing unmet therapeutic need has inspired numerous studies in the field. Integrating the published genomic data available in the Gene Expression Omnibus… read more here.
Keywords: interferon regulatory; regulatory factor; irf6; mice ... See more keywords
Evolution and emergence of primate‐specific interferon regulatory factor 9
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28521
Abstract: The binding of interferon (IFN) to its receptors leads to formation of IFN‐stimulated gene factor 3 (ISGF3) complex that activates the transcription of cellular IFN‐regulated genes. IFN regulatory factor 9 (IRF9, also called ISGF3γ or… read more here.
Keywords: canonical irf9; primate specific; irf9; regulatory factor ... See more keywords
Global regulatory factor AaLaeA upregulates the production of antitumor substances in the endophytic fungus Alternaria alstroemeria
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Basic Microbiology"
DOI: 10.1002/jobm.202200391
Abstract: The global regulatory factor LaeA has been shown to be involved in the biosynthesis of secondary metabolites in various fungi. In a previous work, we isolated an endophytic fungus from Artemisia annua, and its extract… read more here.
Keywords: global regulatory; antitumor; endophytic fungus; alternaria alstroemeria ... See more keywords
Association of interferon regulatory factor 5 (IRF5) gene polymorphisms with juvenile idiopathic arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Rheumatology"
DOI: 10.1007/s10067-018-4010-9
Abstract: Interferon regulatory factor 5 (IRF5) is a member of IRF family which induce signaling pathways and are involved in modulation of cell growth, differentiation, apoptosis, and immune system activity. Juvenile idiopathic arthritis (JIA) is an… read more here.
Keywords: irf5; jia; factor irf5; interferon regulatory ... See more keywords
A rapid method for solubilization of chimeric human interferon regulatory factor-1 (IRF-1) protein in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06260-w
Abstract: Interferon regulatory factor-1 (IRF-1) is a vertebrate transcription factor that plays significant roles in cell cycle regulation, anti-viral response, tumor suppression and immune response. High-level expression of recombinant IRF-1 at 37 °C leads to the formation… read more here.
Keywords: irf; interferon regulatory; factor irf; regulatory factor ... See more keywords
Duck interferon regulatory factor 1 acts as a positive regulator in duck innate antiviral response
Sign Up to like & getrecommendations! Published in 2018 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2017.09.004
Abstract: ABSTRACT In mammals, IFN regulatory factor (IRF) 1 can activates cellular genes and promotes viral resistance against some DNA and RNA viruses. Most IRFs have been identified as critical regulators in the IFN responses in… read more here.
Keywords: duirf1; regulatory factor; positive regulator; duck ... See more keywords
Chicken interferon regulatory factor 7 (IRF7) can control ALV-J virus infection by triggering type I interferon production through affecting genes related with innate immune signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2021.104026
Abstract: In order to breed new birds with strong disease resistance, it is necessary to first understand the mechanism of avian antiviral response. Interferon regulatory factor 7 (IRF7) is not only a member of type I… read more here.
Keywords: infection; regulatory factor; interferon; signaling pathway ... See more keywords
Genetic variants of interferon regulatory factor 5 associated with the risk of community-acquired pneumonia.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.08.080
Abstract: Interferon regulatory factor 5 (IRF5) is a key transcription factor involved in the control of the expression of pro-inflammatory cytokines and immune responses to infection, and multiple polymorphisms of the IFR5 gene have been shown… read more here.
Keywords: interferon regulatory; regulatory factor; community acquired; factor ... See more keywords
The Ciona myogenic regulatory factor functions as a typical MRF but possesses a novel N-terminus that is essential for activity.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental biology"
DOI: 10.1016/j.ydbio.2018.10.010
Abstract: Electroporation-based assays were used to test whether the myogenic regulatory factor (MRF) of Ciona intestinalis (CiMRF) interferes with endogenous developmental programs, and to evaluate the importance of its unusual N-terminus for muscle development. We found… read more here.
Keywords: ciona; regulatory factor; mrf; activity ... See more keywords
The multiple roles of interferon regulatory factor family in health and disease
Sign Up to like & getrecommendations! Published in 2024 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-024-01980-4
Abstract: Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly influence the immune system, impacting both physiological and pathological processes. This review explores the diverse functions of nine mammalian IRF members, each featuring conserved domains… read more here.
Keywords: multiple roles; disease; family; interferon regulatory ... See more keywords
Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-59819-7
Abstract: In anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and systemic lupus erythematosus (SLE), glomerulonephritis is a severe kidney complication driven by immune cells, including T cells. However, the mechanisms underlying T cell activation in these contexts remain… read more here.
Keywords: cytotoxicity; interferon regulatory; interferon; type interferon ... See more keywords