Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00831-x
Abstract: Obsessive-compulsive disorder is a severe psychiatric disorder linked to abnormalities in glutamate signaling and the cortico-striatal circuit. We sequenced coding and regulatory elements for 608 genes potentially involved in obsessive-compulsive disorder in human, dog, and… read more here.
Keywords: compulsive disorder; obsessive compulsive; evolutionary regulatory; disorder ... See more keywords
Gordon H. Dixon’s trace in my personal career and the quantic jump experienced in regulatory information
Sign Up to like & getrecommendations! Published in 2018 at "Systems Biology in Reproductive Medicine"
DOI: 10.1080/19396368.2018.1503752
Abstract: ABSTRACT Even before Rosalin Franklin had discovered the DNA double helix, in her impressive X-ray diffraction image pattern, Erwin Schröedinger, described, in his excellent book, What is Life, how the finding of aperiodic crystals in… read more here.
Keywords: personal career; information; dna; regulatory information ... See more keywords
Identifying Circular RNA and Predicting Its Regulatory Interactions by Machine Learning
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.00655
Abstract: Circular RNA (circRNA) is a closed long non-coding RNA (lncRNA) formed by covalently closed loops through back-splicing. Emerging evidence indicates that circRNA can influence cellular physiology through various molecular mechanisms. Thus, accurate circRNA identification and… read more here.
Keywords: machine; machine learning; circular rna; regulatory information ... See more keywords