Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22201-4
Abstract: The transition from naive to primed pluripotency is accompanied by an extensive reorganisation of transcriptional and epigenetic programmes. However, the role of transcriptional enhancers and three-dimensional chromatin organisation in coordinating these developmental programmes remains incompletely… read more here.
Keywords: human pluripotent; pluripotent states; pluripotent; gene regulatory ... See more keywords
Evolution of opposing regulatory interactions underlies the emergence of eukaryotic cell cycle checkpoints
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DOI: 10.1038/s41598-021-90384-3
Abstract: In eukaryotes the entry into mitosis is initiated by activation of cyclin-dependent kinases (CDKs), which in turn activate a large number of protein kinases to induce all mitotic processes. The general view is that kinases… read more here.
Keywords: opposing regulatory; interactions underlies; cell cycle; cycle ... See more keywords
Experiment level curation of transcriptional regulatory interactions in neurodevelopment.
Sign Up to like & getrecommendations! Published in 2021 at "PLoS computational biology"
DOI: 10.1371/journal.pcbi.1009484
Abstract: To facilitate the development of large-scale transcriptional regulatory networks (TRNs) that may enable in-silico analyses of disease mechanisms, a reliable catalogue of experimentally verified direct transcriptional regulatory interactions (DTRIs) is needed for training and validation.… read more here.
Keywords: dtris; evidence; experiment level; regulatory interactions ... See more keywords
Integrated analysis of lncRNA-associated ceRNA network identified potential regulatory interactions in osteosarcoma
Sign Up to like & getrecommendations! Published in 2020 at "Genetics and Molecular Biology"
DOI: 10.1590/1678-4685-gmb-2019-0090
Abstract: Abstract This study aimed to identify potential therapeutic targets in osteosarcoma (OS) through the network analysis of competing endogenous RNAs (ceRNAs). The differentially expressed miRNAs (DEMIs) and mRNAs (DEMs) were identified between OS cell lines… read more here.
Keywords: analysis; cerna network; cbx7; mir 34a ... See more keywords
Collection and Curation of Transcriptional Regulatory Interactions in Aspergillus nidulans and Neurospora crassa Reveal Structural and Evolutionary Features of the Regulatory Networks
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.00027
Abstract: Transcriptional regulation has important roles in various biological processes (e.g., development and metabolism) in filamentous fungi. However, regulatory interactions between transcription factors (TFs) and their target genes in these species have only been described in… read more here.
Keywords: neurospora crassa; interactions aspergillus; nidulans neurospora; regulatory interactions ... See more keywords
Comprehensive Analysis of Serum Small Extracellular Vesicles-Derived Coding and Non-Coding RNAs from Retinoblastoma Patients for Identifying Regulatory Interactions
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14174179
Abstract: Simple Summary The diagnosis of retinoblastoma (RB) is usually made by clinical examination and imaging modalities. Routine tissue biopsy is not done due to the risk of extraocular spread. Blood-based RNA cargoes could be promising… read more here.
Keywords: extracellular vesicles; coding rnas; serum; analysis ... See more keywords