The regulatory landscape of genetically engineered crops in Pakistan
Sign Up to like & getrecommendations! Published in 2024 at "Food and Energy Security"
DOI: 10.1002/fes3.494
Abstract: Genome editing technology has become part and parcel of biotechnological approach to understand the genetic basis of different biological processes in an organism and for its application in different fields. The basic need of world… read more here.
Keywords: genome edited; genetically engineered; edited crops; act ... See more keywords
An evolutionary perspective of regulatory landscape dynamics in development and disease.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2018.06.009
Abstract: The organization of animal genomes into topologically associating domains (TADs) provides a structural scaffold in which cis-regulatory elements (CREs) operate on their target genes. Determining the position of CREs and genes relative to TADs has… read more here.
Keywords: landscape dynamics; evolutionary perspective; gene expression; disease ... See more keywords
Deciphering the Gene Regulatory Landscape Encoded in DNA Biophysical Features
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.10.055
Abstract: Summary Gene regulation in higher organisms involves a sophisticated interplay between genetic and epigenetic mechanisms. Despite advances, the logic in selective usage of certain genomic regions as regulatory elements remains unclear. Here we show that… read more here.
Keywords: gene regulatory; landscape; regulatory landscape; gene ... See more keywords
The regulatory landscape of a core maize domestication module controlling bud dormancy and growth repression
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11774-w
Abstract: Many domesticated crop plants have been bred for increased apical dominance, displaying greatly reduced axillary branching compared to their wild ancestors. In maize, this was achieved through selection for a gain-of-function allele of the TCP… read more here.
Keywords: regulatory landscape; maize; domestication; increased apical ... See more keywords
The impact of pro-inflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Nature genetics"
DOI: 10.1038/s41588-019-0524-6
Abstract: The early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic β cells. Here we show that exposure to proinflammatory cytokines reveals a marked plasticity of… read more here.
Keywords: cell regulatory; islet; genetics; type diabetes ... See more keywords
Regulatory landscape of applications of AI in measurement endeavors for medical diagnostics
Sign Up to like & getrecommendations! Published in 2025 at "Measurement Science and Technology"
DOI: 10.1088/1361-6501/ae104d
Abstract: Image-based medical diagnostics, particularly in pathology, presents unique challenges due to the complexity and variability of high-resolution medical images. Traditionally dependent on the subjective expertise of experienced clinicians, this field is undergoing a transformation through… read more here.
Keywords: landscape applications; pathology; applications measurement; medical diagnostics ... See more keywords
Commentary on: Adipose-Derived Stem Cells in Aesthetic Surgery A Mixed Methods Evaluation of the Current Clinical Trial, Intellectual Property, and Regulatory Landscape
Sign Up to like & getrecommendations! Published in 2018 at "Aesthetic Surgery Journal"
DOI: 10.1093/asj/sjx177
Abstract: Adipose-derived stem cells (ADSC) continue to incite controversy in the medical profession, are highly sought after by the public, incite excitement in commercial companies, and are seen as a lucrative income generator in clinics. This… read more here.
Keywords: landscape; derived stem; aesthetic surgery; regulatory landscape ... See more keywords
spongEffects: ceRNA modules offer patient-specific insights into the miRNA regulatory landscape
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad276
Abstract: Motivation Cancer is one of the leading causes of death worldwide. Despite significant improvements in prevention and treatment, mortality remains high for many cancer types. Hence, innovative methods that use molecular data to stratify patients… read more here.
Keywords: mirna regulatory; insights mirna; regulatory landscape; spongeffects cerna ... See more keywords
The regulatory landscape of multiple brain regions in outbred heterogeneous stock rats
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac912
Abstract: Heterogeneous Stock (HS) rats are a genetically diverse outbred rat population that is widely used for studying genetics of behavioral and physiological traits. Mapping Quantitative Trait Loci (QTL) associated with transcriptional changes would help to… read more here.
Keywords: brain regions; regulatory landscape; brain; heterogeneous stock ... See more keywords
xQTLatlas: a comprehensive resource for human cellular-resolution multi-omics genetic regulatory landscape
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae837
Abstract: Abstract Understanding how genetic variants influence molecular phenotypes in different cellular contexts is crucial for elucidating the molecular and cellular mechanisms behind complex traits, which in turn has spurred significant advances in research into molecular… read more here.
Keywords: multi omics; cellular resolution; genetic regulatory; cell ... See more keywords
The gene regulatory landscape driving mouse gonadal supporting cell differentiation
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1101/2024.12.09.627451
Abstract: Gonadal sex determination relies on tipping a delicate balance involving the activation and repression of several transcription factors and signalling pathways. This is likely mediated by numerous non-coding regulatory elements that shape sex-specific transcriptomic programs.… read more here.
Keywords: regulatory elements; landscape driving; sex; mouse ... See more keywords