An evolutionary perspective of regulatory landscape dynamics in development and disease.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2018.06.009
Abstract: The organization of animal genomes into topologically associating domains (TADs) provides a structural scaffold in which cis-regulatory elements (CREs) operate on their target genes. Determining the position of CREs and genes relative to TADs has… read more here.
Keywords: landscape dynamics; evolutionary perspective; gene expression; disease ... See more keywords
Deciphering the Gene Regulatory Landscape Encoded in DNA Biophysical Features
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.10.055
Abstract: Summary Gene regulation in higher organisms involves a sophisticated interplay between genetic and epigenetic mechanisms. Despite advances, the logic in selective usage of certain genomic regions as regulatory elements remains unclear. Here we show that… read more here.
Keywords: gene regulatory; landscape; regulatory landscape; gene ... See more keywords
The regulatory landscape of a core maize domestication module controlling bud dormancy and growth repression
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11774-w
Abstract: Many domesticated crop plants have been bred for increased apical dominance, displaying greatly reduced axillary branching compared to their wild ancestors. In maize, this was achieved through selection for a gain-of-function allele of the TCP… read more here.
Keywords: regulatory landscape; maize; domestication; increased apical ... See more keywords
The impact of pro-inflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Nature genetics"
DOI: 10.1038/s41588-019-0524-6
Abstract: The early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic β cells. Here we show that exposure to proinflammatory cytokines reveals a marked plasticity of… read more here.
Keywords: cell regulatory; islet; genetics; type diabetes ... See more keywords
Commentary on: Adipose-Derived Stem Cells in Aesthetic Surgery A Mixed Methods Evaluation of the Current Clinical Trial, Intellectual Property, and Regulatory Landscape
Sign Up to like & getrecommendations! Published in 2018 at "Aesthetic Surgery Journal"
DOI: 10.1093/asj/sjx177
Abstract: Adipose-derived stem cells (ADSC) continue to incite controversy in the medical profession, are highly sought after by the public, incite excitement in commercial companies, and are seen as a lucrative income generator in clinics. This… read more here.
Keywords: landscape; derived stem; aesthetic surgery; regulatory landscape ... See more keywords
spongEffects: ceRNA modules offer patient-specific insights into the miRNA regulatory landscape
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad276
Abstract: Motivation Cancer is one of the leading causes of death worldwide. Despite significant improvements in prevention and treatment, mortality remains high for many cancer types. Hence, innovative methods that use molecular data to stratify patients… read more here.
Keywords: mirna regulatory; insights mirna; regulatory landscape; spongeffects cerna ... See more keywords
The regulatory landscape of multiple brain regions in outbred heterogeneous stock rats
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac912
Abstract: Heterogeneous Stock (HS) rats are a genetically diverse outbred rat population that is widely used for studying genetics of behavioral and physiological traits. Mapping Quantitative Trait Loci (QTL) associated with transcriptional changes would help to… read more here.
Keywords: brain regions; regulatory landscape; brain; heterogeneous stock ... See more keywords
Probing the sRNA regulatory landscape of P. aeruginosa: post‐transcriptional control of determinants of pathogenicity and antibiotic susceptibility
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Microbiology"
DOI: 10.1111/mmi.13857
Abstract: During environmental adaptation bacteria use small regulatory RNAs (sRNAs) to repress or activate expression of a large fraction of their proteome. We extended the use of the in vivo RNA proximity ligation method toward probing… read more here.
Keywords: srna; srna regulatory; probing srna; aeruginosa post ... See more keywords
The regulatory landscape of neurite development in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.974208
Abstract: Neuronal communication requires precise connectivity of neurite projections (axons and dendrites). Developing neurites express cell-surface receptors that interpret extracellular cues to enable correct guidance toward, and connection with, target cells. Spatiotemporal regulation of neurite guidance… read more here.
Keywords: regulatory landscape; development; caenorhabditis elegans; neurite development ... See more keywords