Regulatory Landscaping: How Enhancer-Promoter Communication Is Sculpted in 3D.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.05.032
Abstract: During embryogenesis, precise gene transcription in space and time requires that distal enhancers and promoters communicate by physical proximity within gene regulatory landscapes. To achieve this, regulatory landscapes fold in nuclear space, creating complex 3D… read more here.
Keywords: promoter communication; regulatory landscapes; enhancer promoter; promoter ... See more keywords
Cis-regulatory landscapes in the evolution and development of the mammalian skull
Sign Up to like & getrecommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2022.0079
Abstract: Extensive morphological variation found in mammals reflects the wide spectrum of their ecological adaptations. The highest morphological diversity is present in the craniofacial region, where geometry is mainly dictated by the bony skull. Mammalian craniofacial… read more here.
Keywords: development; cis regulatory; mammalian skull; regulatory landscapes ... See more keywords
Regulatory Landscapes of Nppa and Nppb.
Sign Up to like & getrecommendations! Published in 2021 at "Circulation Research"
DOI: 10.1161/circresaha.120.318495
Abstract: The coordinated expression of the ≈20 000 genes in the human genome is achieved by the concerted action of almost 1 million cis-regulatory regions.1 Many of these regions correspond to enhancers, controlling gene expression through… read more here.
Keywords: nppa nppb; expression; regulatory elements; landscapes nppa ... See more keywords