Identification of limb-specific Lmx1b auto-regulatory modules with Nail-patella syndrome pathogenicity
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25844-5
Abstract: LMX1B haploinsufficiency causes Nail-patella syndrome (NPS; MIM 161200), characterized by nail dysplasia, absent/hypoplastic patellae, chronic kidney disease, and glaucoma. Accordingly in mice, Lmx1b has been shown to play crucial roles in the development of the… read more here.
Keywords: patella syndrome; limb; nail patella; lmx1b ... See more keywords
PCRMS: a database of predicted cis-regulatory modules and constituent transcription factor binding sites in genomes.
Sign Up to like & getrecommendations! Published in 2022 at "Database : the journal of biological databases and curation"
DOI: 10.1093/database/baac024
Abstract: More accurate and more complete predictions of cis-regulatory modules (CRMs) and constituent transcription factor (TF) binding sites (TFBSs) in genomes can facilitate characterizing functions of regulatory sequences. Here, we developed a database predicted cis-regulatory modules… read more here.
Keywords: factor binding; database; constituent transcription; transcription factor ... See more keywords
Characterization of regulatory modules controlling leaf angle in maize.
Sign Up to like & getrecommendations! Published in 2022 at "Plant physiology"
DOI: 10.1093/plphys/kiac308
Abstract: Leaf angle is an important agronomic trait determining maize (Zea mays) planting density and light penetration into the canopy and contributes to the yield gain in modern maize hybrids. However, little is known about the… read more here.
Keywords: regulatory modules; leaf angle; angle; modules controlling ... See more keywords
BiModule: Biclique Modularity Strategy for Identifying Transcription Factor and microRNA Co-Regulatory Modules
Sign Up to like & getrecommendations! Published in 2020 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2019.2896155
Abstract: Systematic identification of gene regulatory modules can provide invaluable knowledge towards understanding aberrant transcriptional/post-transcriptional collaborative regulatory (co-regulatory) effects in cancer. Transcription factor (TF) and microRNA (miRNA) are known as two classes of prominent regulators that… read more here.
Keywords: biclique modularity; modularity strategy; bimodule; factor microrna ... See more keywords
Discovery of microRNAs and Transcription Factors Co-Regulatory Modules by Integrating Multiple Types of Genomic Data
Sign Up to like & getrecommendations! Published in 2017 at "IEEE Transactions on NanoBioscience"
DOI: 10.1109/tnb.2017.2649560
Abstract: It is well known that regulators known as microRNA (miRNA) and transcription factor (TF) have been found to play an important role in gene regulation. However, there are few researches of collaborative regulatory (co-regulatory) mechanism… read more here.
Keywords: tfs genes; transcription; mirnas tfs; genomic data ... See more keywords
Regulatory modules of human thermogenic adipocytes: functional genomics of large cohort and Meta-analysis derived marker-genes
Sign Up to like & getrecommendations! Published in 2021 at "BMC Genomics"
DOI: 10.1186/s12864-021-08126-8
Abstract: Background Recently, ProFAT and BATLAS studies identified brown and white adipocytes marker genes based on analysis of large databases. They offered scores to determine the thermogenic status of adipocytes using the gene-expression data of these… read more here.
Keywords: marker; analysis; functional genomics; regulatory modules ... See more keywords
Identification of long non-coding RNA-microRNA-mRNA regulatory modules and their potential roles in drought stress response in wheat (Triticum aestivum L.)
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1011064
Abstract: Drought is one of the most severe abiotic stresses that influence wheat production across the globe. Understanding the molecular regulatory network of wheat in response to drought is of great importance in molecular breeding. Noncoding… read more here.
Keywords: wheat; regulatory modules; drought stress; response ... See more keywords
Regulatory Modules of Metabolites and Protein Phosphorylation in Arabidopsis Genotypes With Altered Sucrose Allocation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.891405
Abstract: Multi-omics data sets are increasingly being used for the interpretation of cellular processes in response to environmental cues. Especially, the posttranslational modification of proteins by phosphorylation is an important regulatory process affecting protein activity and/or… read more here.
Keywords: regulatory modules; protein phosphorylation; modules metabolites; allocation ... See more keywords
Integrating Expression Data-Based Deep Neural Network Models with Biological Networks to Identify Regulatory Modules for Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11091291
Abstract: Simple Summary The growing evidence suggested that competing endogenous RNAs (ceRNAs) have significant associations with tumor occurrence and progression, yet the regulatory mechanism of them in lung adenocarcinoma remains unclear. Identification of the regulatory modules… read more here.
Keywords: modules lung; network; lung adenocarcinoma; expression ... See more keywords
Identifying Tissue- and Cohort-Specific RNA Regulatory Modules in Cancer Cells Using Multitask Learning
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14194939
Abstract: Simple Summary Understanding the underlying biological mechanisms of primary tumors is crucial for predicting how tumors respond to therapies and exploring accurate treatment strategies. miRNA–mRNA interactions have a major effect on many biological processes that… read more here.
Keywords: mirna mrna; cohort specific; regulatory modules; cancer ... See more keywords