Appendages and gene regulatory networks: Lessons from the limbless
Sign Up to like & getrecommendations! Published in 2018 at "genesis"
DOI: 10.1002/dvg.23078
Abstract: Among squamate reptiles, dozens of lineages have independently evolved complete or partial limb reduction. This remarkable convergence of limbless and limb‐reduced phenotypes provides multiple natural replicates of different ages to explore the evolution and development… read more here.
Keywords: limb; limb reduced; gene regulatory; appendages gene ... See more keywords
Transcriptional regulatory networks of the proteasome in mammalian systems
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2586
Abstract: The tight regulation of proteostasis is essential for physiological cellular function. Mammalian cells possess a network of mechanisms that ensure proteome integrity under normal or stress conditions. The proteasome, being the major cellular proteolytic machinery,… read more here.
Keywords: proteasome mammalian; networks proteasome; regulatory networks; mammalian systems ... See more keywords
Expression and regulatory networks of Mycobacterium tuberculosis PE/PPE family antigens
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27608
Abstract: PE/PPE family antigens are distributed mainly in pathogenic mycobacteria and serve as potential antituberculosis (TB) vaccine components. Some PE/PPE family antigens can regulate the host innate immune response, interfere with macrophage activation and phagolysosome fusion,… read more here.
Keywords: regulatory networks; expression regulatory; family antigens; ppe family ... See more keywords
Methods for Predicting CircRNA-miRNA-mRNA Regulatory Networks: GreenCircRNA and PlantCircNet Databases as Study Cases.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1645-1_11
Abstract: Circular RNAs are molecules formed by 3'-5' ligation in a splicing reaction, the so-called backsplicing. Well described in other groups, especially in humans, circRNA studies that include prediction and validation in plants are recent. It… read more here.
Keywords: predicting circrna; methods predicting; circrna mirna; regulatory networks ... See more keywords
MicroRNA Regulatory Networks as Biomarkers in Obesity: The Emerging Role.
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DOI: 10.1007/978-1-4939-7046-9_18
Abstract: Even though it is a pandemic health problem worldwide, the pathogenesis of obesity is poorly understood. Recently, emerging studies verified that microRNAs (miRNAs) are involved in complicated metabolic processes including adipocyte differentiation, fat cell formation… read more here.
Keywords: obesity emerging; microrna regulatory; emerging role; networks biomarkers ... See more keywords
The SQUAD Method for the Qualitative Modeling of Regulatory Networks.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8618-7_9
Abstract: The wealth of molecular information provided by high-throughput technologies has enhanced the efforts dedicated to the reconstruction of regulatory networks in diverse biological systems. This information, however, has proven to be insufficient for the construction… read more here.
Keywords: method qualitative; qualitative modeling; modeling regulatory; squad method ... See more keywords
Gene Regulatory Networks from Single Cell Data for Exploring Cell Fate Decisions.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9224-9_10
Abstract: Single cell experimental techniques now allow us to quantify gene expression in up to thousands of individual cells. These data reveal the changes in transcriptional state that occur as cells progress through development and adopt… read more here.
Keywords: single cell; gene regulatory; cell data; regulatory networks ... See more keywords
The core regulatory networks and hub genes regulating flower development in Chrysanthemum morifolium
Sign Up to like & getrecommendations! Published in 2020 at "Plant Molecular Biology"
DOI: 10.1007/s11103-020-01017-8
Abstract: The study has facilitated important insights into the regulatory networks involved in flower development in chrysanthemum (Asteraceae), and is informative with respect to the mechanism of flower shape determination. Chrysanthemum morifolium, valued as an ornamental… read more here.
Keywords: network; flower development; regulatory networks; development chrysanthemum ... See more keywords
Fitting structure to function in gene regulatory networks
Sign Up to like & getrecommendations! Published in 2017 at "History and Philosophy of the Life Sciences"
DOI: 10.1007/s40656-017-0164-z
Abstract: Cascades of transcriptional regulation are the common source of the forward drive in all developmental systems. Increases in complexity and specificity of gene expression at successive stages are based on the collaboration of varied combinations… read more here.
Keywords: transcription; gene regulatory; fitting structure; regulatory networks ... See more keywords
Computational methods for Gene Regulatory Networks reconstruction and analysis: A review
Sign Up to like & getrecommendations! Published in 2019 at "Artificial intelligence in medicine"
DOI: 10.1016/j.artmed.2018.10.006
Abstract: In the recent years, the vast amount of genetic information generated by new-generation approaches, have led to the need of new data handling methods. The integrative analysis of diverse-nature gene information could provide a much-sought… read more here.
Keywords: analysis; gene regulatory; used network; computational methods ... See more keywords
A framework to shift basins of attraction of gene regulatory networks through batch reinforcement learning.
Sign Up to like & getrecommendations! Published in 2020 at "Artificial intelligence in medicine"
DOI: 10.1016/j.artmed.2020.101853
Abstract: A major challenge in gene regulatory networks (GRN) of biological systems is to discover when and what interventions should be applied to shift them to healthy phenotypes. A set of gene activity profiles, called basin… read more here.
Keywords: shift; gene regulatory; batch reinforcement; reinforcement learning ... See more keywords