Acidity‐Biodegradable Iridium‐Coordinated Nanosheets for Amplified Ferroptotic Cell Death Through Multiple Regulatory Pathways
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202562
Abstract: Ferroptosis‐based treatment strategies display the potential to suppress some malignant tumors with intrinsic apoptosis resistance. However, current related cancer treatments are still hampered by insufficient intracellular reactive oxygen species (ROS) levels and Fe2+ contents, posing… read more here.
Keywords: coordinated nanosheets; regulatory pathways; biodegradable iridium; multiple regulatory ... See more keywords
A New Perspective on Drugs for Duchenne Muscular Dystrophy: Proposals for Better Respiratory Outcomes and Improved Regulatory Pathways
Sign Up to like & getrecommendations! Published in 2024 at "Paediatric Drugs"
DOI: 10.1007/s40272-024-00673-3
Abstract: New drugs for Duchenne muscular dystrophy (DMD) are emerging rapidly. However, we and others believe these drugs are achieving regulatory approval prematurely. It is the cardiorespiratory complications of DMD that cause the disease's major morbidities… read more here.
Keywords: duchenne muscular; regulatory pathways; drugs duchenne; drug ... See more keywords
Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.05.005
Abstract: Summary Loss of functional cardiomyocytes is a major determinant of heart failure after myocardial infarction. Previous high throughput screening studies have identified a few microRNAs (miRNAs) that can induce cardiomyocyte proliferation and stimulate cardiac regeneration… read more here.
Keywords: common regulatory; mir 199a; cardiomyocyte proliferation; proliferation ... See more keywords
Smyd3-associated regulatory pathways in cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2016.08.008
Abstract: SMYD3 is a member of the SET and MYND-domain family of methyl-transferases, the increased expression of which correlates with poor prognosis in various types of cancer. In liver and colon tumors, SMYD3 is localized in… read more here.
Keywords: smyd3; cancer smyd3; associated regulatory; smyd3 associated ... See more keywords
Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10710-2
Abstract: The survival of ischaemic cardiomyocytes after myocardial infarction (MI) depends on the formation of new blood vessels. However, endogenous neovascularization is inefficient and the regulatory pathways directing coronary vessel growth are not well understood. Here… read more here.
Keywords: adult; coronary vessel; vessel; regulatory pathways ... See more keywords
Advancing vaccines justice through international regulatory pathways.
Sign Up to like & getrecommendations! Published in 2025 at "Global public health"
DOI: 10.1080/17441692.2025.2566730
Abstract: ABSTRACT Vaccines are essential for preventing infectious diseases and promoting population health; however, equitable global access to vaccines remains elusive. Regulatory approval of vaccines is a critical step on the path towards global vaccines justice,… read more here.
Keywords: justice; regulatory pathways; advancing vaccines; vaccines justice ... See more keywords
Conditional Approval Pathways: The “Special” Case of Global Regenerative Medicine Regulation
Sign Up to like & getrecommendations! Published in 2017 at "Rejuvenation Research"
DOI: 10.1089/rej.2017.1932
Abstract: B iomedical innovation and the societal benefits it catalyses is essential and challenging. Yet from reductionist viewpoint, the term innovation has been consistently misapplied to describe the process of translating scientific advancements from the laboratory… read more here.
Keywords: medicine; accelerated regulatory; approval pathways; regulatory pathways ... See more keywords
Advances in understanding the graft healing mechanism: a review of factors and regulatory pathways
Sign Up to like & getrecommendations! Published in 2024 at "Horticulture Research"
DOI: 10.1093/hr/uhae175
Abstract: Abstract Grafting is a widely used technique for asexual plant reproduction, especially in agriculture and forestry. This procedure is used to shorten the seedling period, improve the structure of scion branches, and help plants adapt… read more here.
Keywords: review; regulatory pathways; graft; graft healing ... See more keywords
Treatment Options, Regulatory Pathways and Global Patterns of Use for Cardiac Implantable Devices in Patients With Titanium Allergy.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of cardiovascular electrophysiology"
DOI: 10.1111/jce.70195
Abstract: Titanium hypersensitivity is an uncommon but important challenge in patients requiring cardiac implantable electronic devices (CIEDs). Reactions are difficult to predict, often mimic infection, and complicate timely diagnosis. read more here.
Keywords: titanium; cardiac implantable; treatment options; regulatory pathways ... See more keywords
Roles of naïve CD4+ T cells and their differentiated subtypes in lung adenocarcinoma and underlying potential regulatory pathways
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-024-05530-y
Abstract: Naïve CD4+ T cells and their differentiated counterparts play a significant regulatory role in the tumor immune microenvironment, yet their effects on lung adenocarcinoma (LUAD) are not fully understood. We utilized Mendelian randomization to assess… read more here.
Keywords: potential regulatory; cells differentiated; cd4 cells; lung adenocarcinoma ... See more keywords
Renin–angiotensin system inhibitors positively impact on multiple aging regulatory pathways: Could they be used to protect against human aging?
Sign Up to like & getrecommendations! Published in 2024 at "Physiological Reports"
DOI: 10.14814/phy2.16094
Abstract: The renin–angiotensin system (RAS)—a classical blood pressure regulator—largely contributes to healthy organ development and function. Besides, RAS activation promotes age‐related changes and age‐associated diseases, which are attenuated/abolished by RAS‐blockade in several mammalian species. RAS‐blockers also… read more here.
Keywords: angiotensin system; aging regulatory; regulatory pathways; renin angiotensin ... See more keywords