Titer improvement of milbemycins via coordinating metabolic competition and transcriptional co‐activation controlled by Streptomyces antibiotic regulatory protein family regulator in Streptomyces bingchenggensis
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28044
Abstract: Streptomyces bingchenggensis is a promising producer of milbemycins (MILs), the macrolide pesticide used widely in agriculture. The relationship between different biosynthetic gene clusters (BGCs) and the MIL BGC remains unclear, which hinders the precise metabolic… read more here.
Keywords: titer improvement; metabolic competition; regulatory protein; titer ... See more keywords
Towards detecting regulatory protein-metabolite interactions.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2017.07.006
Abstract: New mapping approaches have greatly expanded our view on the cellular landscape of protein-metabolite interactions. These methods either identify proteins interacting with a selected metabolite or vice versa. By reviewing recent developments, we found that… read more here.
Keywords: protein; detecting regulatory; regulatory protein; metabolite interactions ... See more keywords
Molecular basis for lethal cross-talk between two unrelated bacterial transcription factors - the regulatory protein of a restriction-modification system and the repressor of a defective prophage
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac914
Abstract: Abstract Bacterial gene expression depends on the efficient functioning of global transcriptional networks, however their interconnectivity and orchestration rely mainly on the action of individual DNA binding proteins called transcription factors (TFs). TFs interact not… read more here.
Keywords: two unrelated; regulatory protein; repressor defective; transcription factors ... See more keywords
Targeting the cluster of differentiation 47/signal-regulatory protein alpha axis in myeloid malignancies.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in hematology"
DOI: 10.1097/moh.0000000000000691
Abstract: PURPOSE OF REVIEW The antitumor activity of macrophages is regulated by a balance of prophagocytic and antiphagocytic signals. Cluster of differentiation 47 (CD47), the dominant macrophage immune checkpoint ('do not eat me' signal), interacts with… read more here.
Keywords: regulatory protein; myeloid malignancies; myeloid; protein alpha ... See more keywords
HpaP, a novel regulatory protein with ATPase and phosphatase activity, contributes to full virulence in Xanthomonas campestris pv. campestris
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Microbiology"
DOI: 10.1111/1462-2920.14046
Abstract: The ability of the bacterial phytopathogen Xanthomonas campestris pv. campestris (Xcc) to cause disease is dependent on the type III secretion system (T3SS). Proteins of the Xcc T3SS are encoded by hrp (hypersensitive response and… read more here.
Keywords: protein; phosphatase; virulence; regulatory protein ... See more keywords
Glucokinase Regulatory Protein as a Putative Target for Gestational Diabetes Mellitus and Related Complications: Evidence From the Mendelian Randomization Study
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Diabetes"
DOI: 10.1111/1753-0407.70056
Abstract: Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and is highly associated with adverse perinatal outcomes and long‐term health problems for the mother and offspring. However, there are respective limitations… read more here.
Keywords: glucokinase regulatory; gestational diabetes; diabetes mellitus; target ... See more keywords
Cyclophilin D participates in the inhibitory effect of high‐fat diet on the expression of steroidogenic acute regulatory protein
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14569
Abstract: The high‐fat diet (HFD)–induced obesity is responsible for the testosterone deficiency (TD). However, the mechanism remains unknown. Mitochondrial homeostasis is proved to be important for maintaining the function of steroidogenic acute regulatory protein (StAR), the… read more here.
Keywords: fat diet; regulatory protein; acute regulatory; high fat ... See more keywords
The leucine‐responsive regulatory protein SCAB_Lrp modulates thaxtomin biosynthesis, pathogenicity, and morphological development in Streptomyces scabies
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Plant Pathology"
DOI: 10.1111/mpp.13285
Abstract: Abstract Streptomyces scabies is the best‐characterized plant‐pathogenic streptomycete, which is a special species among the large genus Streptomyces. The pathogenicity of S. scabies relies on the production of the secondary metabolite thaxtomin A. Little is… read more here.
Keywords: lrp; scab lrp; regulatory protein; pathogenicity ... See more keywords
Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways
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DOI: 10.1371/journal.ppat.1009662
Abstract: Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that SIRPA decreased in vitro infection by a number of pathogenic viruses, including… read more here.
Keywords: anti viral; signal regulatory; regulatory protein; sirpa ... See more keywords
KH-type splicing regulatory protein is involved in esophageal squamous cell carcinoma progression
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20926
Abstract: KH-type splicing regulatory protein (KHSRP) is a multifunctional RNA-binding protein, which is involved in several post-transcriptional aspects of RNA metabolism, including microRNA (miRNA) biogenesis. It affects distinct cell functions in different tissues and can have… read more here.
Keywords: regulatory protein; squamous cell; type splicing; splicing regulatory ... See more keywords
Deciphering the role of signal regulatory protein α in immunotherapy for solid tumors
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1612234
Abstract: Therapies targeting immune checkpoints like programmed death receptor-1 and programmed death ligand-1 have demonstrated remarkable effectiveness in combating cancer. However, a subset of patients fails to respond to these therapies, underscoring the complexity of tumor… read more here.
Keywords: deciphering role; role signal; tumor; regulatory protein ... See more keywords