T-follicular helper cells are epigenetically poised to transdifferentiate into T-regulatory type 1 cells
Sign Up to like & getrecommendations! Published in 2024 at "eLife"
DOI: 10.1101/2024.05.17.594762
Abstract: Chronic antigenic stimulation can trigger the formation of IL-10-producing T-regulatory type 1 (TR1) cells in vivo. We have recently shown that T follicular helper (TFH) cells are precursors of TR1 cells and that the TFH-to-TR1… read more here.
Keywords: follicular helper; cell; tfh; regulatory type ... See more keywords
Transcriptional re-programming of insulin B-chain epitope-specific T-follicular helper cells into anti-diabetogenic T-regulatory type-1 cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1177722
Abstract: Systemic delivery of nanoparticles (NPs) coated with mono-specific autoimmune disease-relevant peptide-major histocompatibility complex class II (pMHCII) molecules can resolve organ inflammation in various disease models in a disease-specific manner without impairing normal immunity. These compounds… read more here.
Keywords: follicular helper; insulin chain; regulatory type; pmhcii ... See more keywords