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   Articles with "reinitiation" as a keyword



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The ABC(E1)s of Ribosome Recycling and Reinitiation.

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recommendations! Published in 2017 at "Molecular cell"

DOI: 10.1016/j.molcel.2017.05.017

Abstract: In a recent issue of Nature Structural & Molecular Biology, Heuer et al. (2017) present a 3.9-Å cryo-EM structure of the 40S:ABCE1 post-splitting complex. This structure provides new insights into a dual role for ABCE1 in… read more here.

Keywords: reinitiation; recycling reinitiation; abc ribosome; ribosome recycling ... See more keywords
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Translational coupling via termination-reinitiation in archaea and bacteria

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-11999-9

Abstract: The genomes of many prokaryotes contain substantial fractions of gene pairs with overlapping stop and start codons (ATGA or TGATG). A potential benefit of overlapping gene pairs is translational coupling. In 720 genomes of archaea… read more here.

Keywords: gene pairs; reinitiation; overlapping gene; archaea bacteria ... See more keywords
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Does eIF3 promote reinitiation after translation of short upstream ORFs also in mammalian cells?

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recommendations! Published in 2017 at "RNA Biology"

DOI: 10.1080/15476286.2017.1353863

Abstract: ABSTRACT Reinitiation after translation of short upstream ORFs (uORFs) represents one of the means of regulation of gene expression on the mRNA-specific level in response to changing environmental conditions. Over the years it has been… read more here.

Keywords: reinitiation translation; reinitiation; translation short; translation ... See more keywords
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Do plants drive translation reinitiation to dodge nonsense-mediated decay?

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recommendations! Published in 2022 at "Journal of Experimental Botany"

DOI: 10.1093/jxb/erac444

Abstract: This article comments on: Cymerman MA, Saul H, Farhi R, Vexler K, Gottlieb D, Berezin I, Shaul O. 2023. Plant transcripts with long or structured upstream open reading frames in the NDL2 5ʹ UTR can… read more here.

Keywords: reinitiation; nonsense mediated; drive translation; plants drive ... See more keywords
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Drop-off-reinitiation triggered by EF-G-driven mistranslocation and its alleviation by EF-P

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac068

Abstract: Abstract In ribosomal translation, peptidyl transfer occurs between P-site peptidyl-tRNA and A-site aminoacyl-tRNA, followed by translocation of the resulting P-site deacylated-tRNA and A-site peptidyl-tRNA to E and P site, respectively, mediated by EF-G. Here, we… read more here.

Keywords: peptidyl; reinitiation; site peptidyl; trna site ... See more keywords
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In vivo evidence that eIF3 stays bound to ribosomes elongating and terminating on short upstream ORFs to promote reinitiation

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recommendations! Published in 2017 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkx049

Abstract: Abstract Translation reinitiation is a gene-specific translational control mechanism characterized by the ability of some short upstream ORFs to prevent recycling of the post-termination 40S subunit in order to resume scanning for reinitiation downstream. Its… read more here.

Keywords: reinitiation; vivo evidence; upstream orfs; short upstream ... See more keywords
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Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock

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recommendations! Published in 2019 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkz261

Abstract: Abstract The non-canonical initiation factor DENR promotes translation reinitiation on mRNAs harbouring upstream open reading frames (uORFs). Moreover, DENR depletion shortens circadian period in mouse fibroblasts, suggesting involvement of uORF usage and reinitiation in clock… read more here.

Keywords: charting denr; clock; reinitiation; translation reinitiation ... See more keywords
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Impact of Early Reinitiation of Neuropsychiatric Medications on Agitation and Delirium in the Intensive Care Unit: A Retrospective Study

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recommendations! Published in 2020 at "Annals of Pharmacotherapy"

DOI: 10.1177/1060028020935589

Abstract: Background: Approximately 17% of intensive care unit (ICU) patients are prescribed at least 1 home neuropsychiatric medication (NPM). When abruptly discontinued, withdrawal symptoms may occur manifesting as agitation or delirium in the ICU setting. Objective:… read more here.

Keywords: care unit; reinitiation; intensive care; delirium ... See more keywords
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Ribosome reinitiation can explain length-dependent translation of messenger RNA

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recommendations! Published in 2017 at "PLoS Computational Biology"

DOI: 10.1371/journal.pcbi.1005592

Abstract: Models of mRNA translation usually presume that transcripts are linear; upon reaching the end of a transcript each terminating ribosome returns to the cytoplasmic pool before initiating anew on a different transcript. A consequence of… read more here.

Keywords: length; reinitiation; transcript; translation ... See more keywords
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Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals

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recommendations! Published in 2018 at "PLoS Pathogens"

DOI: 10.1371/journal.ppat.1006792

Abstract: Therapeutic strategies aimed at achieving antiretroviral therapy (ART)-free HIV remission in infected individuals are under active investigation. Considering the vast majority of HIV-infected individuals experience plasma viral rebound upon cessation of therapy, clinical trials evaluating… read more here.

Keywords: antiretroviral therapy; infected individuals; reinitiation; hiv ... See more keywords
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Hopping and Flipping of RNA Polymerase on DNA during Recycling for Reinitiation after Intrinsic Termination in Bacterial Transcription

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recommendations! Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms22052398

Abstract: Two different molecular mechanisms, sliding and hopping, are employed by DNA-binding proteins for their one-dimensional facilitated diffusion on nonspecific DNA regions until reaching their specific target sequences. While it has been controversial whether RNA polymerases… read more here.

Keywords: diffusion; reinitiation; dna; one dimensional ... See more keywords