Effects of a histone deacetylase 3 inhibitor on extinction and reinstatement of cocaine self-administration in rats
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DOI: 10.1007/s00213-018-5122-2
Abstract: RationaleA challenge in treating substance use disorder is that successful treatment often does not persist, resulting in relapse and continued drug seeking. One approach to persistently weaken drug-seeking behaviors is to pair exposure to drug-associated… read more here.
Keywords: inhibitor; reinstatement; extinction; drug ... See more keywords
Intra-accumbal Cannabinoid Agonist Attenuated Reinstatement but not Extinction Period of Morphine-Induced Conditioned Place Preference; Evidence for Different Characteristics of Extinction Period and Reinstatement
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DOI: 10.1007/s11064-017-2374-x
Abstract: The brain reward system consists of the ventral tegmental area that sends its dopaminergic projections to the forebrain, cortical areas, amygdala and largely to the nucleus accumbens (NAc). The present study aims were to investigate… read more here.
Keywords: reinstatement; morphine; extinction; extinction period ... See more keywords
Glucocorticoid receptors in the basolateral amygdala mediated the restraint stress-induced reinstatement of methamphetamine-seeking behaviors in rats
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.04.022
Abstract: HighlightsBlockade of GRs in the BLA slightly reduced the reinstatement to METH induced by acute restraint stress.Blockade of GRs in the BLA dose‐dependently decreased the reinstatement to METH induced by chronic restraint stress.Blockade of the… read more here.
Keywords: grs bla; reinstatement; stress; restraint stress ... See more keywords
Reinstatement after human feature-positive discrimination learning
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DOI: 10.1016/j.beproc.2017.01.007
Abstract: In two experiments, using an online conditioned suppression task, we investigated the possibility of reinstatement of extinguished feature-target compound presentations after sequential feature-positive discrimination training in humans. Furthermore, given a hierarchical account of Pavlovian modulation… read more here.
Keywords: feature positive; reinstatement; feature; group ... See more keywords
Medial temporal lobe reinstatement of content-specific details predicts source memory
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DOI: 10.1016/j.cortex.2016.09.011
Abstract: Leading theories propose that when remembering past events, medial temporal lobe (MTL) structures reinstate the neural patterns that were active when those events were initially encoded. Accurate reinstatement is hypothesized to support detailed recollection of… read more here.
Keywords: reinstatement; source; mtl; content ... See more keywords
Neurofeedback helps to reveal a relationship between context reinstatement and memory retrieval
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DOI: 10.1016/j.neuroimage.2019.06.001
Abstract: Theories of mental context and memory posit that successful mental context reinstatement enables better retrieval of memories from the same context, at the expense of memories from other contexts. To test this hypothesis, we had… read more here.
Keywords: reinstatement; retrieval; context reinstatement; recall ... See more keywords
The blockade of D1- and D2-like dopamine receptors within the dentate gyrus attenuates food deprivation stress-induced reinstatement of morphine-extinguished conditioned place preference in rats
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2020.172967
Abstract: The high rate of relapse to drug abuse is one of the main problems in the treatment of addiction. Stress plays an essential role in relapsing to drug abuse. The present study investigates the role… read more here.
Keywords: reinstatement; morphine; dopamine receptors; stress ... See more keywords
Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2016.187
Abstract: The mechanisms by which stressful life events increase the risk of relapse in recovering cocaine addicts are not well understood. We previously reported that stress, via elevated corticosterone, potentiates cocaine-primed reinstatement of cocaine seeking following… read more here.
Keywords: preference; reinstatement; corticosterone; cocaine primed ... See more keywords
A-Kinase Anchoring Protein 150 (AKAP150) Promotes Cocaine Reinstatement by Increasing AMPA Receptor Transmission in the Accumbens Shell
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DOI: 10.1038/npp.2017.297
Abstract: Previous work indicated that activation of D1-like dopamine receptors (D1DRs) in the nucleus accumbens shell promoted cocaine seeking through a process involving the activation of PKA and GluA1-containing AMPA receptors (AMPARs). A-kinase anchoring proteins (AKAPs)… read more here.
Keywords: cocaine reinstatement; accumbens shell; reinstatement; transmission ... See more keywords
Sequential cocaine-alcohol self-administration produces adaptations in rat nucleus accumbens core glutamate homeostasis that are distinct from those produced by cocaine self-administration alone
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DOI: 10.1038/s41386-019-0452-2
Abstract: There are currently no FDA-approved medications to reduce cocaine relapse. The majority of preclinical studies aimed at identifying the neurobiology underlying relapse involve the self-administration of cocaine alone, whereas many, if not a majority, of… read more here.
Keywords: self administration; reinstatement; cocaine alcohol; cocaine ... See more keywords
Role of mu, but not delta or kappa, opioid receptors in context‐induced reinstatement of oxycodone seeking
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DOI: 10.1111/ejn.13955
Abstract: Relapse to non‐medical use of prescription opioids often occurs after exposure to places previously associated with drug use. Here, we describe a rat model of context‐induced reinstatement of oxycodone seeking after repeated cycles of drug… read more here.
Keywords: reinstatement; oxycodone seeking; reinstatement oxycodone; context induced ... See more keywords