Mammalian target of rapamycin complex 1 and its downstream effector collapsin response mediator protein‐2 drive reinstatement of alcohol reward seeking
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DOI: 10.1111/adb.12653
Abstract: Alcohol use disorder is a chronic relapsing disease. Maintaining abstinence represents a major challenge for alcohol‐dependent patients. Yet the molecular underpinnings of alcohol relapse remain poorly understood. In the present study, we investigated the potential… read more here.
Keywords: target; mtorc1; reinstatement alcohol; alcohol ... See more keywords
Blockade of orexin receptors in the infralimbic cortex prevents stress‐induced reinstatement of alcohol‐seeking behaviour in alcohol‐dependent rats
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DOI: 10.1111/bph.16015
Abstract: A major problem managing alcohol use disorder is the high vulnerability to relapse, even after long periods of abstinence. Chronic alcohol use dysregulates stress responsivity, rendering this system hyporesponsive and making individuals vulnerable to relapse.… read more here.
Keywords: infralimbic cortex; induced reinstatement; stress induced; alcohol ... See more keywords