c-Rel dependant Chk2 signalling regulates the DNA damage response limiting hepatocarcinogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32781
Abstract: BACKGROUND AND AIMS Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. c-Rel, an NF-κB transcription factor family subunit is typically pro-tumourigenic, however, it has recently been reported as a tumour suppressor. Here we… read more here.
Keywords: genotoxic injury; dna damage; rel; damage response ... See more keywords
SLC52A3 expression is activated by NF-κB p65/Rel-B and serves as a prognostic biomarker in esophageal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-018-2757-4
Abstract: The human riboflavin transporter-3 (encoded by SLC52A3) plays a prominent role in riboflavin absorption. Interestingly, abnormal expression patterns of SLC52A3 in multiple types of human cancers have been recently noted. However, the molecular mechanisms underlying… read more here.
Keywords: rel; expression; cancer; p65 rel ... See more keywords
On Monoids in the Category of Sets and Relations
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DOI: 10.1007/s10773-017-3304-z
Abstract: The category Rel is the category of sets (objects) and relations (morphisms). Equipped with the direct product of sets, Rel is a monoidal category. Moreover, Rel is a locally posetal 2-category, since every homset Rel(A,B)… read more here.
Keywords: category; monoids category; category sets; sets relations ... See more keywords
Indications and Outcomes of Re-Exploratory Laparotomy in Adult Living Donor Liver Transplantation—Single-Center Experience of 1352 Consecutive Liver Transplantations from Indian Subcontinent
Sign Up to like & getrecommendations! Published in 2017 at "Indian Journal of Surgery"
DOI: 10.1007/s12262-017-1606-2
Abstract: Liver transplantation (LT) is the gold standard for end-stage liver disease (Prince Postgrad Med J 78:135–141, 2002). LT is a technically demanding operation. It needs experienced surgical team along with good anesthesia and critical care… read more here.
Keywords: study; transplantation; liver transplantation; donor liver ... See more keywords
NF-κB c-Rel Dictates the Inflammatory Threshold by Acting as a Transcriptional Repressor
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DOI: 10.1016/j.isci.2020.100876
Abstract: Summary NF-κB/Rel family of transcription factors plays a central role in initiation and resolution of inflammatory responses. Here, we identified a function of the NF-κB subunit c-Rel as a transcriptional repressor of inflammatory genes. Genetic… read more here.
Keywords: transcriptional repressor; repressor; inflammatory threshold; rel dictates ... See more keywords
The relationship of REL proto-oncogene to pathobiology and chemoresistance in follicular and transformed follicular lymphoma.
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia research"
DOI: 10.1016/j.leukres.2017.01.001
Abstract: Follicular lymphoma (FL) is a common type of indolent lymphoma that occasionally transforms to more aggressive B-cell lymphomas. These transformed follicular lymphomas (tFL) are often associated with chemoresistance whose mechanisms are currently unknown. REL, a… read more here.
Keywords: lymphoma; transformed follicular; chemoresistance; follicular lymphoma ... See more keywords
Inhibition of c-REL using siRNA increased apoptosis and decreased proliferation in pre-B ALL blasts: Therapeutic implications.
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia research"
DOI: 10.1016/j.leukres.2017.08.012
Abstract: The c-Rel transcription factor is a unique member of the NF-kB family that has a role in apoptosis, proliferation and cell survival. Overexpression of c-Rel is detected in many human B cell tumors, including B-cell… read more here.
Keywords: cell; apoptosis; proliferation; rel sirna ... See more keywords
Effect of REL-1017 (Esmethadone) on Cholesterol, Triglycerides, PCSK9, and hs-CRP in a Phase 2a Double-Blind Randomized Trial in Patients with MDD
Sign Up to like & getrecommendations! Published in 2022 at "CNS Spectrums"
DOI: 10.1017/s1092852922000578
Abstract: Abstract Background Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality. Hyperlipidemia and vascular subinflammation play critical roles in the pathogenesis of atherosclerosis. Patients with Major Depressive Disorder (MDD) are at higher… read more here.
Keywords: pcsk9 crp; rel 1017; rel; day ... See more keywords
Single-cell transcriptomic analyses of cardiac immune cells reveal that Rel-driven CD72-positive macrophages induce cardiomyocyte injury.
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DOI: 10.1093/cvr/cvab193
Abstract: AIMS The goal of our study was to investigate the heterogeneity of cardiac macrophages (CMφs) in mice with transverse aortic constriction (TAC) via single-cell sequencing and identify a subset of macrophages associated with heart injury.… read more here.
Keywords: single cell; heart; immune cells; injury ... See more keywords
P2433Local blood viscosity and local Reynolds number are associated with coronary plaque calcium and lipid
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DOI: 10.1093/eurheartj/ehz748.0765
Abstract: Despite being a shear-thinning non-Newtonian fluid, most computational fluid dynamic (CFD) simulations assume blood to be a Newtonian fluid with constant viscosity. The use of more realistic assumptions may deepen mechanistic understanding of the relationship… read more here.
Keywords: viscosity; ess; blood; calcium ... See more keywords
1312. Metallo-β-lactamase-Producing Enterobacterales (MBL-EB): Is it Time to Rethink Our Assessment Tools?
Sign Up to like & getrecommendations! Published in 2020 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofaa439.1494
Abstract: We previously reported the potent in vivo activity of ceftazidime/avibactam human-simulated regimen (HSR) against MBL-EB despite the observed resistance in vitro and the lack of avibactam MBL-inhibitory activity (AAC 2014 Nov;58(11):7007-9). Similar to avibactam, relebactam… read more here.
Keywords: fep rel; lactamase; hsr; activity ... See more keywords