CDKN2A deletion in supratentorial ependymoma with RELA alteration indicates a dismal prognosis: a retrospective analysis of the HIT ependymoma trial cohort
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02169-z
Abstract: Pediatric supratentorial ependymomas with RELA fusions (RELA-EP) have been identified as a unique novel tumor entity [9, 10]. Fusions between C11orf95 and RELA pathologically activate the NFκB signaling pathway indicated by nuclear accumulation of p65-RelA.… read more here.
Keywords: rela; p16 protein; cdkn2a deletion; cdkn2a ... See more keywords
C11orf95-RELA fusions and upregulated NF-KB signalling characterise a subset of aggressive supratentorial ependymomas that express L1CAM and nestin
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-2767-y
Abstract: Ependymomas (EPN) show site specific genetic alterations and a recent DNA methylation profiling study identified nine molecular subgroups. C11orf95-RELA and YAP1 fusions characterise the RELA and YAP1 molecular subgroups, respectively, of supratentorial (ST)-EPNs. Current guidelines… read more here.
Keywords: rela; yap1; l1cam; c11orf95 rela ... See more keywords
MicroRNA-520c-3p suppresses vascular endothelium dysfunction by targeting RELA and regulating the AKT and NF-κB signaling pathways
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-020-00779-5
Abstract: Endothelial injury, which can cause endothelial inflammation and dysfunction, is an important mechanism for the development of atherosclerotic plaque. This study aims to investigate the functional role of miR-520c-3p in vascular endothelium during inflammatory diseases… read more here.
Keywords: rela; signaling pathways; vascular endothelium; targeting rela ... See more keywords
Repeat exposure to polyinosinic:polycytidylic acid induces TLR3 expression via JAK-STAT signaling and synergistically potentiates NFκB-RelA signaling in ARPE-19 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.109494
Abstract: Dry age-related macular degeneration (AMD), accounting for approximately 90% of AMD cases, is characterized by photoreceptor death, retinal pigment epithelium (RPE) dysfunction and, ultimately, geographic atrophy - the localized death of RPE leading to loss… read more here.
Keywords: rela; tlr3; stat signaling; exposure ... See more keywords
Co-regulation of CodY and (p)ppGpp synthetases on morphology and pathogenesis of Streptococcus suis.
Sign Up to like & getrecommendations! Published in 2019 at "Microbiological research"
DOI: 10.1016/j.micres.2019.04.001
Abstract: CodY and (p)ppGpp synthetases are two important global regulators of bacteria. In some pathogens, such as Listeria monocytogenes, the GTP pool links these two regulatory systems, and introducing a codY mutant into the ΔrelA strain… read more here.
Keywords: ppgpp synthetases; rela; cody; cody ppgpp ... See more keywords
relA is Achilles' heel for mycobacterial pathogens as demonstrated with deletion mutants in Mycobacterium avium subsp. paratuberculosis and mycobacterium bovis bacillus Calmette-Guérin (BCG).
Sign Up to like & getrecommendations! Published in 2020 at "Tuberculosis"
DOI: 10.1016/j.tube.2020.101904
Abstract: Studies with Mycobacterium avium subsp. paratuberculosis (Map) in cattle revealed deletion of relA, a global regulator gene, abrogated ability of the mutant to establish a persistent infection, attributed to development of an immune response that… read more here.
Keywords: rela; response; deletion; bcg rela ... See more keywords
Acetylation state of RelA modulated by epigenetic drugs prolongs survival and induces a neuroprotective effect on ALS murine model
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30659-4
Abstract: Dysregulation in acetylation homeostasis has been implicated in the pathogenesis of the amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. It is known that the acetylation of transcriptional factors regulates their activity. The acetylation state… read more here.
Keywords: rela; acetylation; acetylation state; sod1 g93a ... See more keywords
The proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-κB/RELA
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DOI: 10.1038/s44319-024-00339-8
Abstract: The protein interactome of p65/RELA, the most active subunit of the transcription factor (TF) NF-κB, has not been previously determined in living cells. Using p65-miniTurbo fusion proteins and biotin tagging, we identify >350 RELA interactors… read more here.
Keywords: rela; transcription factor; protein interactome; gene ... See more keywords
MC3/SAINT-O-Somes, a novel liposomal delivery system for efficient and safe delivery of siRNA into endothelial cells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of liposome research"
DOI: 10.1080/08982104.2023.2187821
Abstract: Increased understanding of chronic inflammatory diseases and the role of endothelial cell (EC) activation herein, have urged interest in sophisticated strategies to therapeutically intervene in activated EC to treat these diseases. Liposome-mediated delivery of therapeutic… read more here.
Keywords: mc3 saint; rela; sirna; saint somes ... See more keywords
EPEN-30. C11ORF95-RELA FUSION PROTEIN ENGAGES NOVEL GENOMIC LOCI TO DRIVE MURINE EPENDYMOMA GROWTH
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.166
Abstract: Abstract RATIONALE Over 70% of supratentorial (ST) ependymoma are characterized by an oncogenic fusion between C11ORF95 and RELA. C11ORF95-RELA fusion is frequently the sole genetic driver detected in ST ependymoma, thus ranking this genomic event… read more here.
Keywords: rela; ependymoma; c11orf95 rela; rela fusion ... See more keywords
TMET-49. ZFTA-RELA ependymomas produce macrophage-associated itaconate as an oncometabolite to epigenetically sustain pathogenic fusion expression
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.1740
Abstract: ZFTA-RELA ependymomas are malignant brain tumors that are frequently lethal. They are defined by fusions formed between the putative chromatin remodeler ZFTA and the NFκB-mediator-RELA. Through a comprehensive metabolic screen, we identified that ZFTA-RELA cells… read more here.
Keywords: rela ependymomas; rela; zfta rela; fusion ... See more keywords