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Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02169-z
Abstract: Pediatric supratentorial ependymomas with RELA fusions (RELA-EP) have been identified as a unique novel tumor entity [9, 10]. Fusions between C11orf95 and RELA pathologically activate the NFκB signaling pathway indicated by nuclear accumulation of p65-RelA.…
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Keywords:
rela;
p16 protein;
cdkn2a deletion;
cdkn2a ... See more keywords
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Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-2767-y
Abstract: Ependymomas (EPN) show site specific genetic alterations and a recent DNA methylation profiling study identified nine molecular subgroups. C11orf95-RELA and YAP1 fusions characterise the RELA and YAP1 molecular subgroups, respectively, of supratentorial (ST)-EPNs. Current guidelines…
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Keywords:
rela;
yap1;
l1cam;
c11orf95 rela ... See more keywords
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Published in 2021 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-020-00779-5
Abstract: Endothelial injury, which can cause endothelial inflammation and dysfunction, is an important mechanism for the development of atherosclerotic plaque. This study aims to investigate the functional role of miR-520c-3p in vascular endothelium during inflammatory diseases…
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Keywords:
rela;
signaling pathways;
vascular endothelium;
targeting rela ... See more keywords
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Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.109494
Abstract: Dry age-related macular degeneration (AMD), accounting for approximately 90% of AMD cases, is characterized by photoreceptor death, retinal pigment epithelium (RPE) dysfunction and, ultimately, geographic atrophy - the localized death of RPE leading to loss…
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Keywords:
rela;
tlr3;
stat signaling;
exposure ... See more keywords
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Published in 2019 at "Microbiological research"
DOI: 10.1016/j.micres.2019.04.001
Abstract: CodY and (p)ppGpp synthetases are two important global regulators of bacteria. In some pathogens, such as Listeria monocytogenes, the GTP pool links these two regulatory systems, and introducing a codY mutant into the ΔrelA strain…
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Keywords:
ppgpp synthetases;
rela;
cody;
cody ppgpp ... See more keywords
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Published in 2020 at "Tuberculosis"
DOI: 10.1016/j.tube.2020.101904
Abstract: Studies with Mycobacterium avium subsp. paratuberculosis (Map) in cattle revealed deletion of relA, a global regulator gene, abrogated ability of the mutant to establish a persistent infection, attributed to development of an immune response that…
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Keywords:
rela;
response;
deletion;
bcg rela ... See more keywords
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Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30659-4
Abstract: Dysregulation in acetylation homeostasis has been implicated in the pathogenesis of the amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. It is known that the acetylation of transcriptional factors regulates their activity. The acetylation state…
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Keywords:
rela;
acetylation;
acetylation state;
sod1 g93a ... See more keywords
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Published in 2023 at "Journal of liposome research"
DOI: 10.1080/08982104.2023.2187821
Abstract: Increased understanding of chronic inflammatory diseases and the role of endothelial cell (EC) activation herein, have urged interest in sophisticated strategies to therapeutically intervene in activated EC to treat these diseases. Liposome-mediated delivery of therapeutic…
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Keywords:
mc3 saint;
rela;
sirna;
saint somes ... See more keywords
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Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.166
Abstract: Abstract RATIONALE Over 70% of supratentorial (ST) ependymoma are characterized by an oncogenic fusion between C11ORF95 and RELA. C11ORF95-RELA fusion is frequently the sole genetic driver detected in ST ependymoma, thus ranking this genomic event…
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Keywords:
rela;
ependymoma;
c11orf95 rela;
rela fusion ... See more keywords
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Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz126.217
Abstract: Immune check-point blockade targeting programmed cell death ligand-1 (PD-L1)/programmed death-1 (PD-1) axis has created paradigm shift in the treatment of advanced cancer. The prognosis of the ‘ST-RELA’ and ‘PF-A’ molecular subgroups of ependymomas (EPN) remains…
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Keywords:
rela;
molecular subgroups;
subgroups ependymomas;
epns ... See more keywords
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Published in 2022 at "Histopathology"
DOI: 10.1111/his.14724
Abstract: In 2017, a subset of cellular variants of myofibroma and myopericytoma with a smooth muscle‐like immunophenotype and harbouring recurrent SRF::RELA gene fusions was reported. Although the anatomical distribution was found to be quite broad, no…
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Keywords:
rela;
differentiation harbouring;
uterine tumours;
srf rela ... See more keywords