EPEN-30. C11ORF95-RELA FUSION PROTEIN ENGAGES NOVEL GENOMIC LOCI TO DRIVE MURINE EPENDYMOMA GROWTH
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DOI: 10.1093/neuonc/noaa222.166
Abstract: Abstract RATIONALE Over 70% of supratentorial (ST) ependymoma are characterized by an oncogenic fusion between C11ORF95 and RELA. C11ORF95-RELA fusion is frequently the sole genetic driver detected in ST ependymoma, thus ranking this genomic event… read more here.
Keywords: rela; ependymoma; c11orf95 rela; rela fusion ... See more keywords
LINC-29. IMPACT OF RELA FUSION ON OUTCOMES OF CHILDHOOD SUPRATENTORIAL EPENDYMOMAS (ST-EPEN)
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DOI: 10.1093/neuonc/noaa222.463
Abstract: Abstract BACKGROUND Ependymomas are heterogenous group of tumours with variable clinical course and diverse molecular features. RELA fusion status has been reported to have prognostic impact in ST-EPEN. Our retrospective study analysed the prevalence and… read more here.
Keywords: impact rela; year; fusion; oncology ... See more keywords
Abstract LB126: RELA fusion-positive ependymoma and diffuse midline glioma treated with VAL-083 under expanded access - case reports
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DOI: 10.1158/1538-7445.am2023-lb126
Abstract: Ependymoma can occur anywhere in the central nervous system (CNS), but often occurs near the ventricle of the brain and central canal of the spinal cord. Ependymoma accounts for 5.7% of all childhood and 1.9%… read more here.
Keywords: ependymoma; positive ependymoma; rela fusion; fusion positive ... See more keywords
Phenotypic characterization with somatic genome editing and gene transfer reveals the diverse oncogenicity of ependymoma fusion genes
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DOI: 10.1186/s40478-020-01080-8
Abstract: Recurrent RELA and YAP1 fusions are intimately associated with tumorigenesis in supratentorial ependymomas. Chromothripsis and focal copy number alterations involving 11q are hallmarks of these tumors. However, it is unknown whether the chromosomal alterations are… read more here.
Keywords: ependymoma; fusion genes; fusion; gene ... See more keywords