Contribution of Myeloid-Drived Suppressor Cells to Leukemia Relapse in Patients with B-ALL Who Underwent Allo-HSCT
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DOI: 10.1182/blood-2019-123723
Abstract: Background:B cell acute lymphoblastic leukemia (B-ALL) is a clonal hematopoietic stem cell neoplasm. Despite advances in its therapeutic strategies, including induction chemotherapy followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT), relapse remains the major barrier… read more here.
Keywords: relapsed patients; allo hsct; mdscs; relapse ... See more keywords
Epigenomic Signatures in Myelodysplastic Syndrome Patients As Predictors of Donor Compatibility and Transplant Outcome
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DOI: 10.1182/blood-2019-127124
Abstract: Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic stem cell disorders for which allogeneic hematopoietic stem cell transplantation (HCT) is currently the only curative treatment. Epigenetic lesions are considered a major pathogenetic determinant in… read more here.
Keywords: methylation; relapsed patients; dmrs; transplant ... See more keywords
Venetoclax induces sustained complete responses in refractory/relapsed patients with cardiac AL amyloidosis.
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DOI: 10.1200/jco.2019.37.15_suppl.e19538
Abstract: e19538 Background: Venetoclax (VEN) is an orally bioavailable small molecule inhibitor of the anti-apoptotic protein BCL-2 and has been shown to have efficacy against myeloma (MM), particularly in patients that harbor t(11;14). Approximately, 50% of… read more here.
Keywords: relapsed patients; treatment; cardiac amyloidosis; refractory relapsed ... See more keywords
CNA Profiling of Single CTCs in Locally Advanced Esophageal Cancer Patients during Therapy Highlights Unexplored Molecular Pathways
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DOI: 10.3390/cancers13246369
Abstract: Simple Summary In the present work, we describe the evolution of circulating tumor cells (CTCs) released into the bloodstreams of 11 patients affected by locally advanced esophageal cancer (EC) during clinical treatments. We aimed at… read more here.
Keywords: advanced esophageal; analysis; relapsed patients; locally advanced ... See more keywords