Analysis of Human Leukocyte Antigen DR Alleles, Immune-Related Adverse Events, and Survival Associated With Immune Checkpoint Inhibitor Use Among Patients With Advanced Malignant Melanoma
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.46400
Abstract: Key Points Question What is the association between immune-related adverse events (irAEs) and survival after immune checkpoint inhibitor (ICI) therapy initiation and human leukocyte antigen genes in patients with advanced malignant melanoma? Findings In this… read more here.
Keywords: advanced malignant; patients advanced; immune related; related adverse ... See more keywords
Association of Immune-Related Adverse Events With Efficacy of Atezolizumab in Patients With Non–Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2022.7711
Abstract: This analysis of pooled data from 3 randomized clinical trials evaluates the association between immune-related adverse events and atezolizumab efficacy in patients with advanced non–small cell lung cancer. read more here.
Keywords: association immune; non small; immune related; small cell ... See more keywords
Association of Opioid-Related Adverse Drug Events With Clinical and Cost Outcomes Among Surgical Patients in a Large Integrated Health Care Delivery System
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Surgery"
DOI: 10.1001/jamasurg.2018.1039
Abstract: Importance Opioids are commonly used for pain control during and after invasive procedures. However, opioid-related adverse drug events (ORADEs) are common and have been associated with worse patient outcomes. Objectives To examine the incidence of… read more here.
Keywords: opioid related; drug events; related adverse; care ... See more keywords
IL‐7 germline variant: setting the stage for immune‐related adverse events
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13392
Abstract: Treatment with immune checkpoint inhibitors (ICIs) is frequently associated with immune‐related adverse events (irAEs). A new study identified an interleukin 7 (IL‐7) allelic variant—rs16906115—as a major risk factor for the development of ICI‐associated irAEs. This… read more here.
Keywords: variant setting; germline variant; immune related; related adverse ... See more keywords
Treatment‐related adverse events of antibody–drug conjugates in clinical trials: A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34507
Abstract: Antibody–drug conjugates (ADCs) have complex molecular structures and have been tested in numerous clinical trials. Therefore, understanding the mechanisms of their toxicity when applied in medical practice is of high importance. read more here.
Keywords: clinical trials; drug conjugates; related adverse; treatment related ... See more keywords
Association between opioid therapy trajectories and potential opioid‐related adverse health events
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.5495
Abstract: We identified associations between membership in seven group‐based trajectories based on supply of filled opioid prescriptions and potential opioid‐related adverse health events over a 720‐day window. read more here.
Keywords: potential opioid; related adverse; health events; opioid related ... See more keywords
Medication-related adverse events in health care-what have we learned? A narrative overview of the current knowledge.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of clinical pharmacology"
DOI: 10.1007/s00228-021-03213-x
Abstract: PURPOSE Although medication-related adverse events (MRAEs) in health care are vastly studied, high heterogeneity in study results complicates the interpretations of the current situation. The main objective of this study was to form an up-to-date… read more here.
Keywords: health care; related adverse; medication; medication related ... See more keywords
Hospitalizations and deaths related to adverse drug events worldwide: Systematic review of studies with national coverage.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of clinical pharmacology"
DOI: 10.1007/s00228-021-03238-2
Abstract: PURPOSE Adverse drug events are related to negative outcomes in healthcare, including hospitalization, increased duration of hospital stay and death. The aim of this study was to conduct a systematic review to evaluate hospitalizations and… read more here.
Keywords: deaths related; drug events; related adverse; hospitalizations deaths ... See more keywords
Susac’s syndrome as an immune-related adverse event after pembrolizumab: a case report
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurology"
DOI: 10.1007/s00415-019-09587-4
Abstract: Immune checkpoint inhibitors are increasingly used in cancer treatment and have a significant impact on survival [1]. Pembrolizumab is a recombinant monoclonal antibody that blocks the programmed death-1 (PD-1) receptor, which is an inhibitor of… read more here.
Keywords: response; immune related; susac syndrome; case ... See more keywords
Immune-related adverse events correlate with improved survival in patients undergoing anti-PD1 immunotherapy for metastatic melanoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-018-2819-x
Abstract: BackgroundTherapeutic chances for metastatic melanoma have consistently changed over the last years with the advent of antibodies targeting the programmed cell death protein-1 (PD-1). Onset of immune-related adverse events (irAEs) during treatment can be a… read more here.
Keywords: related adverse; immune related; metastatic melanoma; anti pd1 ... See more keywords
Cancer immunotherapy–related adverse events: causes and challenges
Sign Up to like & getrecommendations! Published in 2020 at "Supportive Care in Cancer"
DOI: 10.1007/s00520-020-05705-5
Abstract: Despite the success and ongoing promise of monoclonal antibody–targeted immune checkpoint inhibitor immunotherapy of advanced malignancies, in particular, antibodies directed against CTLA-4 and PD-1/PD-L1, the development of immune-related adverse events (irAEs) remains a constraint of… read more here.
Keywords: immune checkpoint; related adverse; cancer immunotherapy; adverse events ... See more keywords