Immune Checkpoint Inhibitors (ICIs)-Related Cardiotoxicity.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-41008-7_15
Abstract: The growing success of immune checkpoint inhibitors (ICIs) has led to effectively treating several types of cancers. Even though their use has been associated with the development of cardiac adverse effects, which may decrease the… read more here.
Keywords: immune checkpoint; checkpoint inhibitors; related cardiotoxicity; icis related ... See more keywords
Cardioprotective effect of renin–angiotensin inhibitors and β-blockers in trastuzumab-related cardiotoxicity
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DOI: 10.1007/s00392-019-01448-4
Abstract: BackgroundTrastuzumab-related cardiotoxicity (TRC) has been considered as reversible. However, recent studies have raised concern against reversibility of left ventricular (LV) systolic dysfunction in breast cancer patients treated with trastuzumab. In addition, the efficacy of medical… read more here.
Keywords: renin angiotensin; inhibitors blockers; angiotensin inhibitors; related cardiotoxicity ... See more keywords
Proteasome Inhibitor-Related Cardiotoxicity: Mechanisms, Diagnosis, and Management
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DOI: 10.1007/s11912-020-00931-w
Abstract: Purpose of Review Multiple myeloma is the second most common hematologic malignancy in the USA, with over 32,000 new cases and nearly 13,000 deaths expected in 2019. The past few decades in myeloma research have… read more here.
Keywords: proteasome inhibitor; related cardiotoxicity; cardiotoxicity mechanisms; cardiotoxicity ... See more keywords
Cardiotoxicity in cancer immune-checkpoint therapy: Mechanisms, clinical evidence, and management strategies.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2021.09.041
Abstract: Immune-checkpoint inhibitors (ICIs), a unique antibody-based therapeutic strategy, have revolutionized the treatment landscape of solid and hematological cancers. Despite the proven benefits of ICIs, the cardiotoxicity from unspecific immune activation (uncommon but potentially fatal) is… read more here.
Keywords: immune checkpoint; related cardiotoxicity; clinical evidence; ici related ... See more keywords
Observational study of trastuzumab-related cardiotoxicity in early and metastatic breast cancer
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DOI: 10.1177/1078155216639755
Abstract: Introduction Trastuzumab-related cardiotoxicity has been a major concern in clinical practice, since observational studies have shown higher incidences than that reported in clinical trials. We aim to measure the incidence of trastuzumab-related cardiotoxicity in patients… read more here.
Keywords: related cardiotoxicity; early metastatic; metastatic breast; cardiotoxicity ... See more keywords
Cardiac Imaging Methods for Chemotherapy-related Cardiotoxicity Screening and Related Radiation Exposure: Current Practice and Trends.
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DOI: 10.21873/anticanres.11584
Abstract: BACKGROUND Radiation exposure is a serious concern with usage of serial multigated acquisition (MUGA) scans (7.8mSv/study) for chemotherapy-related cardiotoxicity (CRC) screening. The current practice with respect to the imaging modalities chosen for cardiotoxicity screening and… read more here.
Keywords: related cardiotoxicity; radiation exposure; chemotherapy related; radiation ... See more keywords
New Insights in Early Detection of Anticancer Drug-Related Cardiotoxicity Using Perfusion and Metabolic Imaging
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DOI: 10.3389/fcvm.2022.813883
Abstract: Cardio-oncology requires a good knowledge of the cardiotoxicity of anticancer drugs, their mechanisms, and their diagnosis for better management. Anthracyclines, anti-vascular endothelial growth factor (VEGF), alkylating agents, antimetabolites, anti-human epidermal growth factor receptor (HER), and… read more here.
Keywords: anticancer drug; drug related; related cardiotoxicity; cardiotoxicity ... See more keywords
Immune Checkpoint Inhibitor-Associated Cardiotoxicity in Solid Tumors: Real-World Incidence, Risk Factors, and Prognostic Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.882167
Abstract: Background Immune checkpoint inhibitors (ICIs) have achieved acknowledged progress in cancer therapy. However, ICI-associated cardiotoxicity as one of the most severe adverse events is potentially life-threatening, with limited real-world studies reporting its predictive factors and… read more here.
Keywords: related cardiotoxicity; cardiotoxicity; ici related; analysis ... See more keywords
Clinical characteristics and management of immune checkpoint inhibitor-related cardiotoxicity: A single-center experience
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DOI: 10.3389/fcvm.2023.1093383
Abstract: Background Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy in the past decade and amplify T-cell-mediated immune responses by disrupting immunoinhibitory signals. The augmented T-cell immune response has led to a range of immune-related adverse… read more here.
Keywords: single center; immune checkpoint; related cardiotoxicity; cardiotoxicity ... See more keywords
Cardiotoxicity Induced by Immune Checkpoint Inhibitors: What a Cardio-Oncology Team Should Know and Do
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DOI: 10.3390/cancers14215403
Abstract: Simple Summary Immune checkpoint inhibitors, including monoclonal antibodies directed against the programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) pathway or the cytotoxic T-lymphocyte antigen-4 (CTLA-4) pathway and the most recent lymphocyte-activation gene 3 (LAG-3)—blocking… read more here.
Keywords: oncology; checkpoint inhibitors; immune checkpoint; related cardiotoxicity ... See more keywords
Shining Damaged Hearts: Immunotherapy-Related Cardiotoxicity in the Spotlight of Nuclear Cardiology
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DOI: 10.3390/ijms23073802
Abstract: The emerging use of immunotherapies in cancer treatment increases the risk of immunotherapy-related cardiotoxicity. In contrast to conventional chemotherapy, these novel therapies have expanded the forms and presentations of cardiovascular damage to a broad spectrum… read more here.
Keywords: shining damaged; related cardiotoxicity; cardiology; damaged hearts ... See more keywords