PDGF pathway in LMNA-related dilated cardiomyopathy
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DOI: 10.1038/s41569-019-0246-6
Abstract: Activation of the PDGF pathway is involved in the pathogenesis of dilated cardiomyopathy caused by mutations in LMNA; this new finding suggests that inhibition of PDGFRβ is a novel therapeutic target for patients with this… read more here.
Keywords: cardiology; lmna related; pathway lmna; pdgf pathway ... See more keywords
Efficacy and Safety of ARRY-371797 in LMNA-Related Dilated Cardiomyopathy: A Phase 2 Study
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DOI: 10.1161/circgen.122.003730
Abstract: Background: Lamin A/C gene (LMNA)-related dilated cardiomyopathy is a serious and life-threatening condition with a high unmet medical need. This phase 2 study assessed the effects of the oral selective p38 mitogen-activated protein kinase inhibitor… read more here.
Keywords: arry 371797; lmna related; related dilated; phase study ... See more keywords
Titin-Related Dilated Cardiomyopathy: The Clinical Trajectory and the Role of Circulating Biomarkers in the Clinical Assessment
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DOI: 10.3390/diagnostics12010013
Abstract: Titin truncating variants (TTNtv) are known as the leading cause of inherited dilated cardiomyopathy (DCM). Nevertheless, it is unclear whether circulating cardiac biomarkers are helpful in detection and risk assessment. We sought to assess 1)… read more here.
Keywords: titin related; related dilated; cardiomyopathy clinical; dilated cardiomyopathy ... See more keywords