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Published in 2020 at "Current Treatment Options in Neurology"
DOI: 10.1007/s11940-020-0610-1
Abstract: Purpose of review The purpose of this review is to summarize and discuss current options and new advances in the treatment of sleep-related hypermotor epilepsy (SHE), focusing on pharmacological and surgical treatments. Recent findings Carbamazepine…
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Keywords:
treatment;
sleep related;
related hypermotor;
hypermotor epilepsy ... See more keywords
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Published in 2021 at "Chest"
DOI: 10.1016/j.chest.2021.01.059
Abstract: Disorders of arousal (DoA) and sleep-related hypermotor epilepsy (SHE) are sleep-related events characterized by complex, often bizarre, and violent behaviors. DoA are involuntary motor manifestations of different complexity occurring during an incomplete awakening from NREM…
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Keywords:
epilepsy;
diagnosis;
sleep related;
related hypermotor ... See more keywords
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Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14974
Abstract: The mechanisms causing spontaneous epileptic seizures, including carbamazepine‐resistant/zonisamide ‐sensitive seizures and comorbidity in autosomal dominant sleep‐related hypermotor epilepsy (ADSHE) are unclear. This study investigated functional abnormalities in thalamocortical transmission in transgenic rats bearing rat S286L‐mutant…
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Keywords:
subunit nicotinic;
hypermotor epilepsy;
sleep related;
related hypermotor ... See more keywords
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Published in 2020 at "Pharmaceuticals"
DOI: 10.3390/ph13050099
Abstract: To understand the pathomechanism and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy (ADSHE), we studied functional abnormalities of glutamatergic transmission in thalamocortical pathway from reticular thalamic nucleus (RTN), mediodorsal thalamic nucleus (MDTN) to orbitofrontal cortex…
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Keywords:
hypermotor epilepsy;
s284l mutant;
sleep related;
related hypermotor ... See more keywords