Depletion of NIMA-related kinase Nek2 induces aberrant self-renewal and apoptosis in stem/progenitor cells of aged muscular tissues
Sign Up to like & getrecommendations! Published in 2022 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2022.111619
Abstract: Frailty of the locomotory organs has become a widespread problem in the geriatric population. The major factor leading to frailty is an age-associated decrease in muscular mass and a reduced number of muscular cells and… read more here.
Keywords: muscular tissues; kinase nek2; self renewal; related kinase ... See more keywords
Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14095
Abstract: Ischaemic heart disease limits oxygen and metabolic substrate availability to the heart, resulting in tissue death. Here, we demonstrate that the AMP-activated protein kinase (AMPK)-related protein Snf1-related kinase (SNRK) decreases cardiac metabolic substrate usage and… read more here.
Keywords: mitochondrial uncoupling; snf1 related; mitochondrial efficiency; related kinase ... See more keywords
Sucrose Nonfermenting-Related Kinase Expression Is Related to a Metabolic Switch in Ovarian Cancer Cells That Results in Increased Fatty Acid Oxidation
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Investigation"
DOI: 10.1080/07357907.2022.2136376
Abstract: Abstract Ovarian cancer frequently metastasizes to the omentum, which is primarily comprised of adipocytes. Our previous study found that sucrose nonfermenting-related kinase (SNRK) expression is lower in advanced-stage compared with early-stage ovarian cancer tissue. In… read more here.
Keywords: sucrose nonfermenting; nonfermenting related; related kinase; ovarian cancer ... See more keywords
Overexpression of NIMA related kinase 2 in multiple myeloma and its relevance with disease features and prognosis to bortezomib treatment
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13723
Abstract: NIMA related kinase 2 (NEK2) promotes the malignant transformation and enhances the chemoresistance to proteasome inhibitor in multiple myeloma (MM) cell lines. The current study aimed to further investigate its correlation with clinical features and… read more here.
Keywords: nima related; related kinase; multiple myeloma; bortezomib treatment ... See more keywords
Tropomyosin-Related Kinase Receptor and Neurotrophin Expression in Cutaneous Melanoma Is Associated with a Poor Prognosis and Decreased Survival
Sign Up to like & getrecommendations! Published in 2019 at "Oncology"
DOI: 10.1159/000499384
Abstract: Objective: Normally, activation of tropomyosin-related kinase (TRK) receptors by neurotrophins (NTs) stimulates intracellular pathways involved in cell survival and proliferation. Dysregulation of NT/TRK signaling may affect neoplasm prognosis. Data on NT and TRK expression in… read more here.
Keywords: melanoma; trk expression; prognosis; related kinase ... See more keywords
NIMA-related kinase 2 overexpression is associated with poor survival in cancer patients: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Management and Research"
DOI: 10.2147/cmar.s188347
Abstract: Objective NIMA-related kinase 2 (NEK2) has been reported to be overexpressed in various types of cancer and correlated with poor prognosis. The role(s) of NEK2 in cancer, however, is still uncertain. The aim of this… read more here.
Keywords: meta analysis; nima related; cancer; cancer patients ... See more keywords
NIMA related kinase 2 promotes gastric cancer cell proliferation via ERK/MAPK signaling
Sign Up to like & getrecommendations! Published in 2019 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v25.i23.2898
Abstract: BACKGROUND NIMA related kinase 2 (NEK2) is closely related to mitosis, and it is currently considered to be over-expressed frequently in many poorly prognostic cancers. However, the effect of the up-regulated NEK2 on cellular signaling… read more here.
Keywords: nima related; erk; proliferation; related kinase ... See more keywords